Search Results
Overview
| Uniprot ID | A0A8W4F695 |
|---|---|
| Protein Name | Prohibitin |
| Gene Name | PHB1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | RARFVVEKAEQQKKA |
| 154 | EKAEQQKKAAIISAE |
Function
In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells
Protein Sequence
10
MAAKVFESIG
20
KFGLALAVAG
30
GVVNSALYND
40
LQNVNITLRI
50
LFRPVASQLP
60
RIFTSIGEDY
70
DERVLPSITT
80
EILKSVVARF
90
DAGELITQRE
100
LVSRQVSDDL
110
TERAATFGLI
120
LDDVSLTHLT
130
FGKEFTEAVE
140
AKQVAQQEAE
150
RARFVVEKAE
160
QQKKAAIISA
170
EGDSKAAELI
180
ANSLATAGDG
190
LIELRKLEAA
200
EDIAYQLSRS
210
RNITYLPAGQ
SVLLQLPQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Biological Process | GO:0071897 | DNA biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.