Search Results
Overview
| Uniprot ID | A0A8W4F6U2 |
|---|---|
| Protein Name | Diphosphomevalonate decarboxylase |
| Gene Name | MVD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 209 | ALLRFRAKALVPARM |
| 37 | TTTAAISKDFTKDRI |
Function
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis
Protein Sequence
10
AWRGKRDEEL
20
ILPINSSLSV
30
TLHQHQLKTT
40
TTAAISKDFT
50
KDRIWLNGRE
60
EDVGQPRIQA
70
CLREIRRLAR
80
KRKSDGDEDA
90
LPLCLSYKVH
100
VASVNNFPTA
110
AGLASSAAGF
120
ACLACALARV
130
YGVEGDLSEV
140
ARRGSGSACR
150
SLYGGFVEWQ
160
MGQRADGKDS
170
IAQQVAPESH
180
WPELRVLILV
190
VSAEKKLMGS
200
TAGMQTSVET
210
SALLRFRAKA
220
LVPARMAEMA
230
RCIRERDFQA
240
FGQLTMKDSN
250
QFHATCLDTF
260
PPISYLSDTS
270
QRVIRLVHRF
280
NAHHGCTKVA
290
YSFDAGPNAV
300
IFALDDTVPE
310
FVAAVQHSFP
320
PEPNGDKFLQ
330
GLPVEPALLS
340
DELKAALGTD
350
PTPGGIRYII
360
ATQVGPGPQV
370
LDDPGAHLLG
PDGLPKLAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004163 | diphosphomevalonate decarboxylase activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.