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Overview

Uniprot IDA0A8W4F713
Protein NameHepatocyte growth factor-regulated tyrosine kinase substrate
Gene NameHGS
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
202 SRCSTIPKFGIEKEV
207 IPKFGIEKEVRVCEP
221 PCYEQLNKKAEGKAA
50 KYAVSSIKKKVNDKN

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation

Protein Sequence

10 MGRGSGTFER 20 LLDKATSQLL 30 LETDWESILQ 40 ICDLIRQGDT 50 QAKYAVSSIK 60 KKVNDKNPHV 70 ALYALEVMES 80 VVKNCGQTVH 90 DEVANKQTME 100 ELKELLKRQV 110 EVSVRNKILH 120 LIQAWAHAFR 130 NEPKYKVVQD 140 TYQIMKVEGH 150 VFPEFKESDA 160 MFAAERAPDW 170 VDAEECHRCR 180 VQFGVMTRKH 190 HCRACGQIFC 200 GKCSSRCSTI 210 PKFGIEKEVR 220 VCEPCYEQLN 230 KKAEGKAAST 240 ELPPEYLTSP 250 LSQQSQLPPK 260 RDETALQEEE 270 ELQLALALSQ 280 SEAEEKERTR 290 QKSAYAAYPK 300 AEPASVASSA 310 PPASSLYSSP 320 VNSSAPLAED 330 IDPELARYLN 340 RNYWEKKQEE 350 ARKSPTPSAP 360 VPLAEPAAQP 370 GEGHAVPASV 380 EYQNGESEES 390 HAQFLKALQN 400 AVSTFVNRVR 410 SNHVRGRSIT 420 NDSAVLSLFQ 430 SINGMHPQLL 440 ELLNQLDERR 450 LYYEGLQDKL 460 AQIRDARGAL 470 SALREEHREK 480 LRRAAEEAER 490 QRQIQLAQKL 500 EIMRQKKQEY 510 LEVQRQLAIQ 520 RLQEQEKERQ 530 LRLEQQKQTI 540 QMRAQMPAFS 550 LPYAQLQAMP 560 TAGGVLYQPS 570 GPASFAGTFS 580 PAGSVEGSPM 590 HTVYMSQPAP 600 AAGGPYPSLP 610 GAAADPSMVG 620 AYMYPAGATG 630 AQTAPPGPAG 640 PTASPAYSSY 650 QPSPAQAYQN 660 VASQPPQSLP 670 AVSQPPQAGA 680 LGYVGGQAVS 690 VGYQPYGMQG 700 LLTALPGQDA 710 PLPPPQQPYL 720 TGQQPVYQQM 730 APSGGPPQQQ 740 PPVAQQPPAQ 750 GPPAQGSEAQ LISFD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0032585 multivesicular body membrane
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.