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Overview

Uniprot IDA0A8W4F732
Protein NameTransducin beta-like protein 3
Gene NameTBL3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
628 RDPESCEKLEATVLQ

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MASRGCKVSP 20 GLRPFCHQLD 30 QTGQHLFCVC 40 GTRVNILDVA 50 SGAVLRSLEQ 60 EDQEDITAFD 70 LSPDDEVLVT 80 ATRALLLAQW 90 AWREGSIVRL 100 WKAIHTAPVA 110 AMAFDPTSTL 120 LATGGCDGAV 130 RVWDVVRHYG 140 THHFRGSPGV 150 VHQGGPAHQR 160 LFPPSSGRDK 170 ICTTVPVFES 180 VEAAVLLPEE 190 PAPELGVKST 200 GLHFLTAGDQ 210 GILRVWEAAS 220 GQCVHAQPRL 230 PGPGQELTHC 240 ALARAAGLLL 250 SVTADHNLLL 260 YEARSLQLQK 270 QFAGYSEEVL 280 DVRFLGPENS 290 HVVVASNSPC 300 LKVFELQTSA 310 CQILHGHTDI 320 VLALDVFRKG 330 WLFASCAKDQ 340 SIRIWRINKA 350 GLVACVAQGS 360 GHTHSVGTIC 370 CSRLKESFLV 380 TGSQDCTVKL 390 WPLPEALPSR 400 STAPDSGPVL 410 LQAQATQRCH 420 DKDINSVAIA 430 PNDKLLATGS 440 QDRTAKLWAL 450 PQCQLLGIFS 460 GHRRGLWCVQ 470 FSPMDQVLAT 480 ASADGTVKLW 490 ALQDFSCLKT 500 FEGHDASVLR 510 VVSGASRCRP 520 SGSDGLVKLW 530 TIKSNECVRT 540 LDAHEDKVWG 550 LHCSRLDDRA 560 LTAASDSRVI 570 LWKDVTEEEQ 580 AEEEARREEE 590 VVRQQELDNL 600 LHEKRYLRAL 610 GLAISLDRPH 620 TVLTVIQAIR 630 RDPESCEKLE 640 ATVLQLRRDQ 650 KEALLRFCVT 660 WNTNSRHCHE 670 AQAVLGMLLR 680 HEAPEELLAY 690 DGVRASLEAL 700 LPYTERHFQR 710 LSRTLQAAAF 720 LDFLWHSMKL 730 PTLPAAPPAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032040 small-subunit processome
Biological Process GO:0006364 rRNA processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.