Search Results

Overview

Uniprot ID	A0A8W4F734
Protein Name	Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Gene Name	MTHFD1L
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
270	RWKLHCLKLQPLSPV
290	ISRAQTPKAVDVLAK
452	NGIREFSKIQLARLK

Function

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

Protein Sequence

10 EVIQNSKEVL 20 SLLQEKNPAF 30 KPVLAVIQAG 40 EDNLMQEINQ 50 KLAEEAGLNI 60 THICLPADSS 70 EDEIIDEILK 80 INEDSRVHGL 90 ALQISETSFS 100 SKILHALKPE 110 KDVDGVTDVN 120 LGKLVRGDAH 130 DCFVSPVARA 140 VIELLEKSGV 150 NLDGRKILVI 160 GAHGSLEATL 170 QCLFQRKGSM 180 TMSSQWKAPQ 190 LQSKLHEADV 200 VIFGSPKPEE 210 VPLSWIQQGT 220 AVLNCSHDFL 230 SGKWLQIGCQ 240 ATENNRSNWS 250 SLWVQQNMVG 260 SGRRWLREQQ 270 YRRWKLHCLK 280 LQPLSPVPSD 290 IEISRAQTPK 300 AVDVLAKEIG 310 LLEDEIEIYG 320 RSKAKVRLSL 330 LERLKDQADG 340 KYVLVAGITP 350 TPLGEGKSTV 360 TIGLVQAMTA 370 HLNVNSFACL 380 RQPSQGPTFG 390 VKGGAAGGGY 400 AQVIPMEEFN 410 LHLTGDIHAI 420 TAANNLLAAA 430 IDTRILHENT 440 QTDKALYNRL 450 VPSVNGIREF 460 SKIQLARLKK 470 LGINKTDPSA 480 LTEDEMRKFA 490 RLDIDPATIT 500 WQRVLDTNDR 510 FLRKITLGRG 520 TQRKAQFDIA 530 VASEIMAVLA 540 LTDSLKDMKE 550 RLGRMVVASD 560 KNGQPVTADD 570 LGVTGALTVL 580 MKDAIKPNLM 590 QTLEGTPVFV 600 HAGPFANIAH 610 GNSSVLADKI 620 ALKLVGEEGF 630 VVTEAGFGAD 640 IGMEKFFNIK 650 CRASGLVPNV 660 VVLVATVRAL 670 KMHGGGPSVT 680 AGVPLKKEYT 690 EENLQLVADG 700 CCNLKKQIQI 710 AQLFGVPVVV 720 ALNVFKTDTR 730 AEIDLVCELA 740 KQAGAFDAVP 750 CYHWSVGGKG 760 SVDLAWAVSE 770 AAHKGSRFQF 780 LYDVQLPIVE 790 KIRTIAQAVY 800 GARDIELSSE 810 AQSKIDRYTE 820 QGFGNLPICM 830 AKTHLSLSHQ 840 PDKKGVPKDF 850 ILPITDVRAS 860 IGAGFIYPLV 870 GTMSTMPGLP 880 TRPCFYDIDL 890 DTETEQVQGL F

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Process	GO:0046394	carboxylic acid biosynthetic process
Biological Process	GO:0015942	formate metabolic process
Biological Process	GO:0006730	one-carbon metabolic process
Biological Process	GO:0046653	tetrahydrofolate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.