Overview
| Uniprot ID | A0A8W4F750 |
|---|
| Protein Name | EARP and GARP complex-interacting protein 1 |
|---|
| Gene Name | EIPR1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 219 |
CGDDCRVKFWDTRKV |
| 51 |
VLATCYNKTADSKVL |
Function
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes
Protein Sequence
10
NPDSAPIIHI
20
IDFDDENNII
30
NKNVLLHRAG
40
EIWHISASPA
50
DKGVLATCYN
60
KTADSKVLTC
70
AAVWRMPAEL
80
EPGGHESPED
90
AASPAHALEL
100
LCHLDHPARG
110
STACVAWEPA
120
GDGKRVISLA
130
DNHLLLWDLQ
140
ESSSQALLAS
150
SASLEGKGQL
160
KFTTGRWSPH
170
HSCTQVATAN
180
DTAVRGWDTR
190
TMSQIYCIEN
200
AHGQLVRDLD
210
FNPNKQYCLA
220
SCGDDCRVKF
230
WDTRKVTEPV
240
RTLEEHSHWV
250
WNVRYNHSHD
260
QLVLTASSDS
270
RVILSNMASI
280
SSEPFGHLVD
290
DDDLSDQEER
300
RPEEKSQEPP
310
QDSVIATYEE
320
HEDSVYAVEW
330
AAADPWLFAS
340
LSYDGRLVVN
350
RVPRALKYRI
LL
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0051049 |
regulation of transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.