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Overview

Uniprot IDA0A8W4F768
Protein NameGelsolin
Gene NameGSN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
134 GGVASGFKHVVPNEV
150 VQRLFQVKGRRVVRA
202 LKATQVSKGIRDNER
295 CFILDHGKDGKIFVW
298 LDHGKDGKIFVWKGK
303 DGKIFVWKGKQANTE
317 EERKAALKTASDFIS
632 RLFACSNKIGRFVIE
685 TEALTSAKRYIETDP

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis

Protein Sequence

10 MPGYAPSTMV 20 VEHPEFLKAG 30 KEPGLQIWRV 40 EKFDLVPVPP 50 NLYGDFFTGD 60 AYVILKTVQL 70 RNGNLQYDLH 80 YWLGNECSQD 90 ESGAAAIFTV 100 QLDDYLNGRA 110 VQHREVQGFE 120 SATFLGYFKS 130 GLKYKKGGVA 140 SGFKHVVPNE 150 VAVQRLFQVK 160 GRRVVRATEV 170 PVSWESFNRG 180 DCFILDLGND 190 IYQWCGSNSN 200 RYERLKATQV 210 SKGIRDNERS 220 GRAHVHVSEE 230 DAEPAGMLQV 240 LGPKPTLPEG 250 TEDTVKEDAA 260 NRKLAKLYKV 270 SNGAGTMTVS 280 LVADENPFAQ 290 GALKSEDCFI 300 LDHGKDGKIF 310 VWKGKQANTE 320 ERKAALKTAS 330 DFISKMNYPK 340 QTQVSVLPEG 350 GETPLFKQFF 360 KNWRDPDQVD 370 GPGLSYLSSH 380 IANVERVPFD 390 AATLHTSTAM 400 AAQHGMDDDG 410 TGQKQIWRIE 420 GSNKVPVDPA 430 TYGQFYGGDS 440 YIILYNYRHG 450 GRQGQIIYNW 460 QGAQSTQDEV 470 AASAILTAQL 480 DEELGGTPVQ 490 SRVVQGKEPA 500 HLMSLFGGKP 510 MIIYRGGTSR 520 EGGQTAPAST 530 RLFQVRASSS 540 GATRAVEVIP 550 KAGALNSNDA 560 FVLKTPSAAY 570 LWVGTGASEA 580 EKTGAQELLR 590 VLRAQPVQVA 600 EGSEPDSFWE 610 ALGGKAAYRT 620 SPRLKDKKMD 630 AHPPRLFACS 640 NKIGRFVIEE 650 VPGELMQEDL 660 ATDDVMLLDT 670 WDQVFVWVGK 680 DSQEEEKTEA 690 LTSAKRYIET 700 DPANRDRRTP 710 INVVKQGFEP 720 PSFVGWFLSW 730 DDNYWSVDPL DRAIAELAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0051014 actin filament severing
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0060271 cilium assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.