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Overview

Uniprot ID	A0A8W4F796
Protein Name	Transcription factor Sp2
Gene Name	SP2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
66	PPQPTPRKLVPIKPA

Function

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites

Protein Sequence

10 MSDPQTSMAA 20 TAAVSPSDYL 30 QPAASTTQDS 40 QPSPLALLAA 50 TCSKIGPPAV 60 EAAVTPPAPP 70 QPTPRKLVPI 80 KPAPLPLSPG 90 KNSFGILSSK 100 GNILQIQGSQ 110 LSTSYPGGQL 120 VFAIQNPTMI 130 NKGTRSNASI 140 QYQAVPQIQA 150 SSSQTIQVQP 160 NLTNQIQIIP 170 GTNQAIITPS 180 PSSHKPVPIK 190 PAPVQKSSTT 200 TTPVQSGANV 210 VKLTGGGGNV 220 TLTLPVNNLV 230 NTSDTGAPTQ 240 LLTESPPAPL 250 SKTNKKARKK 260 SLPASQPPVA 270 VAEQVETVLI 280 ETTADNIIQA 290 GNNLLIVQSP 300 GGGQPAVVQQ 310 VQVVPKAEQQ 320 QVVQIPQQAL 330 RVVQAASATL 340 PTVPQKPSQN 350 FQIQAAEPTP 360 TQVYIRTPSG 370 EVQTVLVQDS 380 PPATVATTAT 390 TTCSSPAPRA 400 AHLSGTSKKH 410 SASILRKERP 420 LPKIAPAGSI 430 ISLNAAQLAA 440 AAQAMQTINI 450 NGVQVQGVPV 460 TITNTGGQQQ 470 LTVQNVSGNN 480 LTISGLSPTQ 490 IQLQMEQALA 500 GEAQPGEKRR 510 RMACTCPNCK 520 DGDKRSGEQG 530 KKKHVCHIPD 540 CGKTFRKTSL 550 LRAHVRLHTG 560 ERPFVCNWFF 570 CGKRFTRSDE 580 LQRHARTHTG 590 DKRFECAQCQ 600 KRFMRSDHLT 610 KHYKTHLVTK NL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.