Overview
| Uniprot ID | A0A8W4F814 |
|---|
| Protein Name | Transcription and mRNA export factor ENY2 |
|---|
| Gene Name | ENY2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 35 |
LKELLRAKLIECGWK |
| 42 |
KLIECGWKDQLKAHC |
Function
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores
Protein Sequence
10
MVSKMNKDAQ
20
MRAAINQKLI
30
ETGERERLKE
40
LLRAKLIECG
50
WKDQLKAHCK
60
EVIKEKGLEH
70
VTVDDLVAEI
80
TPKGRALVPD
90
SVKKELLQRI
100
RTFLAQHASL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071819 |
DUBm complex |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000124 |
SAGA complex |
| Cellular Component |
GO:0070390 |
transcription export complex 2 |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006406 |
mRNA export from nucleus |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0006368 |
transcription elongation by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.