Search Results
Overview
| Uniprot ID | A0A8W4F896 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | IDH3A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 156 | LITEGASKRIAEFAF |
| 202 | REVAENCKDIKFNEM |
| 315 | TACFATIKDGKSLTK |
| 322 | KDGKSLTKDLGGNAK |
| 37 | MKIFDAAKAPIQWEE |
Function
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MAGPAWISKV
20
KTVTLIPGDG
30
IGPEISAAVM
40
KIFDAAKAPI
50
QWEERNVTAI
60
QGPGGKWMIP
70
PEAKESMDKN
80
KMGLKGPLKT
90
PIAAGHPSMN
100
LLLRKTFDLY
110
ANVRPCVSIE
120
GYKTPYTDVN
130
IVTIRENTEG
140
EYSGIEHVIV
150
DGVVQSIKLI
160
TEGASKRIAE
170
FAFEYARNNH
180
RSNVTAVHKA
190
NIMRMSDGLF
200
LQKCREVAEN
210
CKDIKFNEMY
220
LDTVCLNMVQ
230
DPSQFDVLVM
240
PNLYGDILSD
250
LCAGLIGGLG
260
VTPSGNIGAN
270
GVAIFESVHG
280
TAPDIAGKDM
290
ANPTALLLSA
300
VMMLRHMGLF
310
DHAAKIETAC
320
FATIKDGKSL
330
TKDLGGNAKC
340
SDFTEEICRR
VKDLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004449 | isocitrate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.