Search Results

Overview

Uniprot IDA0A8W4F8E8
Protein NameNuclear receptor corepressor 1
Gene NameNCOR1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
107 DHDSLESKRPRLEQV
1101 TRGTPSGKLPVESVP
1193 TAHEISLKRSYESVE
1283 AFEGAISKGKPYDGI
1353 SAIKHNVKSLITGPS
1361 SLITGPSKLPRGLPP
1417 STLHEAPKAQLSPGI
1467 KSTNHERKSTLTPTQ
1837 SSALPSGKPQPHPAV
201 KVEQQILKLKKKQQQ
2271 CKPKLISKSSSRKSK
287 ARKQREQKICQRYDQ
325 KTREYYEKQFPEIRK
652 KNFYFNYKRRHNLDN
665 DNLLQQHKQKTSRKP

Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver

Protein Sequence

10 MSSSGYPPNQ 20 GAFSTEQSRY 30 PSHSVQYTFP 40 SARHQQEFAV 50 PDYRSSHLEV 60 SQASQLLQQQ 70 QQQQLRRRPS 80 LLSEFHPGSD 90 RPQERRSGYE 100 QFHPGPSPVD 110 HDSLESKRPR 120 LEQVSDSHFQ 130 RISAAVLPLV 140 HTLPEGLRSS 150 ADAKKDPAFG 160 VKHEAPSSPL 170 SGQPCGDDQN 180 ASPSKLSKEE 190 LIQSMDRVDR 200 EIAKVEQQIL 210 KLKKKQQQLE 220 EEAAKPPEPE 230 KPVSPPPVEQ 240 KHRSIVQIIY 250 DENRPLYNQP 260 SDTKVYHENI 270 KTNQVMRKKL 280 ILFFKRRNHA 290 RKQREQKICQ 300 RYDQLMEAWE 310 KKVDRIENNP 320 RRKAKESKTR 330 EYYEKQFPEI 340 RKQREQQERF 350 QRVGQRGAGL 360 SATIARSEHE 370 ISEIIDGLSE 380 QENNEKQMRQ 390 LSVIPPMMFD 400 AEQRRVKFIN 410 MNGLMEDPMK 420 VYKDRQFMNV 430 WTDHEKEIFK 440 DKFIQHPKNF 450 GLIASYLERK 460 SVPDCVLYYY 470 LTKKNENYKA 480 LVRRNYGKRR 490 GRNQQQIARP 500 SQEEKVEEKE 510 DDKAEKTEKK 520 EEEKKDEEEK 530 DEKEDSKETT 540 KEKDKTEGTA 550 EEAEEREQAT 560 PRGRKTANSQ 570 GRRKGRVTRS 580 MTNEAAAASA 590 AAAAATEEPP 600 PPLPPPPEPI 610 STEPVETSRW 620 TEEEMEVAKK 630 GLVEHGRNWA 640 AIAKMVGTKS 650 EAQCKNFYFN 660 YKRRHNLDNL 670 LQQHKQKTSR 680 KPREERDVSQ 690 CESVASTVSA 700 QEDEDIEASN 710 EEENPEDSEG 720 AENSSDTESA 730 PSPSPVEAVK 740 PGEDRTEPAA 750 QPEAPAPGDG 760 GEQAPAGDLA 770 AAAAEPMDAG 780 PEERGADAAP 790 APGPPAAEPA 800 DPEPRAPGSP 810 GRVDGDTVQP 820 EPREDGAPRP 830 EPASDHDSSA 840 TCSADEDVDA 850 EPDRQRMFPL 860 DSKPSLLNPT 870 GSMLVSSPIK 880 ANPLDLPQLQ 890 HRAAVIPPMV 900 SCTPCNIPVG 910 TPVSGYALYQ 920 RHIKAMHESA 930 LLEEQRQRQE 940 QIDLECRGST 950 SPCGASKSPG 960 REWEVLQPAP 970 HQVIANLPEG 980 VRLPTTRPTR 990 PPPPLIPSSK 1000 TAVASEKPSF 1010 ILGGSISQGT 1020 PGTYLPSPNQ 1030 ASYAPEAAKP 1040 PAGSISLGLP 1050 RPQEAAKPAA 1060 VPYIKQEEFS 1070 PRSQNSQPEG 1080 LLVRAQHEGV 1090 VRGSTGAIAE 1100 GSITRGTPSG 1110 KLPVESVPSL 1120 RGSITQGTPA 1130 LSQAGIPAEA 1140 LVKGSISRLS 1150 VEESSPEKGR 1160 EEAASKGHVI 1170 YEGKSGHILS 1180 YDNIKNAREG 1190 TRSPRTAHEI 1200 SLKRSYESVE 1210 GALKQGLPVR 1220 ESPGSTPLEG 1230 LICRALPRGS 1240 PHPDLKERTV 1250 PSGSIMQGTP 1260 RATADSFEDG 1270 LKYPKQIKRE 1280 SPPIRAFEGA 1290 ISKGKPYDGI 1300 TTIKEMGRSV 1310 HEIPRQDALT 1320 QESRKTPEVV 1330 PGARPLVEGS 1340 ISQGTPIKFD 1350 SSSGQSAIKH 1360 NVKSLITGPS 1370 KLPRGLPPLE 1380 VVPEGAKAVE 1390 RGKYEDVKAG 1400 EPVRSRHTSV 1410 VSSGPSVLRS 1420 TLHEAPKAQL 1430 SPGIYDEASA 1440 RRTPGSYASP 1450 ASRGSPMLGR 1460 APDVTIASGK 1470 STNHERKSTL 1480 TPTQRESIVA 1490 KSPVPGVDPA 1500 VSHSPFEPHH 1510 RAGAPGEAYR 1520 GHLPTHLDPA 1530 MPFHRALDPA 1540 AAAYLFQRQL 1550 SPTPGYPSQY 1560 QLYAMENTRQ 1570 TILNDYITSQ 1580 QMQVSLRPDV 1590 ARGLSPREQQ 1600 LGLPYPATRG 1610 IIDLTNMPPA 1620 ILVPHPGGTS 1630 TPPMDRITYI 1640 PGTQISFPPR 1650 PYNSASMSPG 1660 HSTHLAVAAS 1670 AEREREKERE 1680 RLAAAAAASS 1690 DLYLRPGSEQ 1700 PSRPSSHGYV 1710 RSPSPSVRAQ 1720 ETVLQQRPSV 1730 FQGTNGTSVI 1740 TPLDPSAQLR 1750 IMPLPAGGPS 1760 ISQGLPASRY 1770 NTAADALAAL 1780 VDAAASAPQM 1790 DVSKTKESKH 1800 EAARLEENLR 1810 SRSAAVSEQQ 1820 QLEQKSLEAE 1830 KRPGQGLYTS 1840 SALPSGKPQP 1850 HPAVVYSEAG 1860 REKGPPPKSR 1870 YEEELRTRGK 1880 TTITAANFID 1890 VIITRQIASD 1900 KDGRERGSQS 1910 SDSSGSLSSH 1920 RYEAPSDAIE 1930 VISPASSPAP 1940 PPERLQAYQP 1950 EVVKASPAEN 1960 EATRQYEGPL 1970 HHYRPQQESP 1980 PPAAPQAEGA 1990 GQVPRTHRLI 2000 TLADHICQII 2010 TQDFARNQVS 2020 AQPPQQPPTS 2030 TFQNSPSALV 2040 STPVRPKTSN 2050 RYSPESQPPS 2060 VHHQRPGSRV 2070 SPENLVDKPR 2080 GSLRPGKSPE 2090 RSHISSEPYE 2100 PVSPPQVPAA 2110 HEKQDGVLLL 2120 APRGPEPPEQ 2130 RSDSRSPGSI 2140 SYLPSFFTKL 2150 ENTSPMVKSK 2160 KQEIFRKLNS 2170 SGGGDSDMAA 2180 AQPGTEIFNL 2190 PAVTTSGAVS 2200 SRGHTFADPA 2210 SNLGLEDIIR 2220 KALMGSFDDK 2230 VEEHGGVLPQ 2240 PGAVVPGGAG 2250 TSVVSSGEAR 2260 REEGDPPPHA 2270 GAVCKPKLIS 2280 KSSSRKSKSP 2290 IPGQGYLGTE 2300 RPSSVSSVHS 2310 EGDYHRQTPG 2320 WAWEDRPSST 2330 GSTQFPYNPL 2340 TLRMLSSTPP 2350 TPVACAPAAT 2360 AAAPAAPHQQ 2370 SRIWEREPAP 2380 LLSAQYETLS DSDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0045922 negative regulation of fatty acid metabolic process
Biological Process GO:0045820 negative regulation of glycolytic process
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:1902894 negative regulation of miRNA transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0048511 rhythmic process
Biological Process GO:0051225 spindle assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.