Search Results

Overview

Uniprot ID	A0A8W4F8T0
Protein Name	Structural maintenance of chromosomes protein 3
Gene Name	SMC3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
106	RRVIGAKKDQYFLDK
561	AFKHVFGKTLICRSM
900	SLKQLFRKLEQCNTE

Function

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement

Protein Sequence

10 MYIKQVIIQG 20 FRSYRDQTIV 30 DPFSSKHNVI 40 VGRNGSGKSN 50 FFYAIQFVLS 60 DEFSHLRPEQ 70 RLALLHEGTG 80 PRVISAFVEI 90 IFDNSDNRLP 100 IDKEEVSLRR 110 VIGAKKDQYF 120 LDKKMVTKND 130 VMNLLESAGF 140 SRSNPYYIVK 150 QGKINQMATA 160 PDSQRLKLLR 170 EVAGTRVYDE 180 RKEESISLMK 190 ETEGKREKIN 200 ELLKYIEERL 210 HTLEEEKEEL 220 AQYQKWDKMR 230 RALEYTIYNQ 240 ELNETRAKLD 250 ELSAKRETSG 260 EKSRQLRDAQ 270 QDARDKMEDI 280 ERQVRELKTK 290 ISAMKEEKEQ 300 LSAERQEQIK 310 QRTKLELKAK 320 DLQDELAGNS 330 EQRKRLLKER 340 QKLLEKIEEK 350 QKELAETEPK 360 FNSVKEKEER 370 GIARLAQATQ 380 ERTDLYAKQG 390 RGSQFTSKEE 400 RDKWIKKELK 410 SLDQAINDKK 420 RQIAAIHKDL 430 EDTEANKEKN 440 LEQYNAILNG 450 IDSINKVLDH 460 FRRKGINQHV 470 QNGYHGIVMN 480 NFECEPAFYT 490 CVEVTAGNRL 500 FYHIVDSDEV 510 STKILMEFNK 520 MNLPGEVTFL 530 PLNKLDVRDT 540 AYPETNDAIP 550 MISKLRYNPR 560 FDKAFKHVFG 570 KTLICRSMEV 580 STQLARAFTM 590 DCITLEGDQV 600 SHRGALTGGY 610 YDTRKSRLEL 620 QKDVRKAEEE 630 LGELEAKLNE 640 NLRRNIERIN 650 NEIDQLMNQM 660 QQIETQQRKF 670 KASRDSILSE 680 MKMLKEKRQQ 690 SEKTFMPKQR 700 SLQSLEASLH 710 AMESTRESLK 720 AELGTDLLSQ 730 LSLEDQKRVD 740 ALNDEIRQLQ 750 QENRQLLNER 760 IKLEGIITRV 770 ETYLNENLRK 780 RLDQVEQELN 790 ELRETEGGTV 800 LTATTSELEA 810 INKRVKDTMA 820 RSEDLDNSID 830 KTEAGIKELQ 840 KSMERWKNME 850 KEHMDAINHD 860 TKELEKMTNR 870 QGMLLKKKEE 880 CMKKIRELGS 890 LPQEAFEKYQ 900 TLSLKQLFRK 910 LEQCNTELKK 920 YSHVNKKALD 930 QFVNFSEQKE 940 KLIKRQEELD 950 RGYKSIMELM 960 NVLELRKYEA 970 IQLTFKQVSK 980 NFSEVFQKLV 990 PGGKATLVMK 1000 KGDVEGSQSQ 1010 DEGEGSGESE 1020 RGSGSQSSVP 1030 SVDQFTGVGI 1040 RVSFTGKQGE 1050 MREMQQLSGG 1060 QKSLVALALI 1070 FAIQKCDPAP 1080 FYLFDEIDQA 1090 LDAQHRKAVS 1100 DMIMELAVHA 1110 QFITTTFRPE 1120 LLESADKFYG 1130 VKFRNKVSHI 1140 DVITAEMAKD FVEDDTTHG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000775	chromosome, centromeric region
Cellular Component	GO:0031981	nuclear lumen
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Biological Process	GO:0051301	cell division
Biological Process	GO:0051276	chromosome organization
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0051321	meiotic cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.