Overview
| Uniprot ID | A0A8W4F9D0 |
|---|
| Protein Name | Cellular tumor antigen p53 |
|---|
| Gene Name | TP53 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 112 |
FLHSGTAKSVTCTYS |
| 284 |
TEEENFLKKGQSCPE |
| 285 |
EEENFLKKGQSCPEP |
| 312 |
TSSSPVQKKKPLDGE |
Function
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression
Protein Sequence
10
MEESQSELGV
20
EPPLSQETFS
30
DLWKLLPENN
40
LLSSELSLAA
50
VNDLLLSPVT
60
NWLDENPDDA
70
SRVPAPPAAT
80
APAPAAPAPA
90
TSWPLSSFVP
100
SQKTYPGSYD
110
FRLGFLHSGT
120
AKSVTCTYSP
130
ALNKLFCQLA
140
KTCPVQLWVS
150
SPPPPGTRVR
160
AMAIYKKSEY
170
MTEVVRRCPH
180
HERSSDYSDG
190
LAPPQHLIRV
200
EGNLRAEYLD
210
DRNTFRHSVV
220
VPYEPPEVGS
230
DCTTIHYNFM
240
CNSSCMGGMN
250
RRPILTIITL
260
EDASGNLLGR
270
NSFEVRVCAC
280
PGRDRRTEEE
290
NFLKKGQSCP
300
EPPPGSTKRA
310
LPTSTSSSPV
320
QKKKPLDGEY
330
FTLQVSSLGE
340
RGAVSCSYSV
350
GLDKGRKATK
360
VAGVRLCPVS
370
LAILSSVHRL
380
DSCSAYYLSG
LRD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0003700 |
DNA-binding transcription factor activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0000976 |
transcription cis-regulatory region binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0048511 |
rhythmic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.