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Overview

Uniprot IDA0A8W4F9D6
Protein NameExportin-5
Gene NameXPO5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1129 LLNPSLQKAADKRRK
1149 LIAGCIGKPLGEQFR
1162 FRKEVHIKNLPSLFK
208 VNKYQQVKTDNAQES
35 RYRLEALKFCEEFKE
41 LKFCEEFKEKCPICV
43 FCEEFKEKCPICVPC
57 CGLRLAEKTQIAIVR
87 NSMSRLEKVYLKNSV
920 LHMRLSQKWQIINQR
969 ITVCCVSKKGADHTA

Function

Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Protein Sequence

10 MAMDQVNALC 20 EELVKAVTVM 30 MDPSSTQRYR 40 LEALKFCEEF 50 KEKCPICVPC 60 GLRLAEKTQI 70 AIVRHFGLQI 80 LEHVVKFRWN 90 SMSRLEKVYL 100 KNSVMELTAN 110 GTLDILEEEN 120 HIKDVLSRIV 130 VEMIKREWPQ 140 HWPDMLVELD 150 TLSKQGETQT 160 ELVMFILLRL 170 AEDVVTFQTL 180 PPQRRRDIQQ 190 TLTQNMEKIF 200 SFLLNTLQEN 210 VNKYQQVKTD 220 NAQESKVRAL 230 SLNTLAGYTD 240 WVSLSHITAE 250 NCKLLEMLCL 260 LLSEQELQLG 270 AAECLLIAVS 280 RKGKLEDRKP 290 LMILFGDAVM 300 HYMLSAAQTA 310 DGGGLVEKHY 320 VFLKRLCQVL 330 CALGSQLCAL 340 LGPDSDVETP 350 ANFGKYLESF 360 LAFTTHPSQF 370 LRSSTQMTWG 380 ALFRHEVLSR 390 DPLLLAIIPK 400 YLRACMTNLV 410 KMGFPSKTDN 420 PSCEYSRLDF 430 DSDEDFNAFF 440 NSSRAQQGEV 450 MRLACRLDPK 460 TSFQMAGEWL 470 KYQLSAAIDT 480 GSMKSGSGES 490 GLCSIFSPSF 500 VQWEAMTFFV 510 EGVVNQMFRT 520 VDKEEIPVND 530 GIELLQMVLN 540 FETKDPLILS 550 CVLTNVSALF 560 SFVTFRPEFL 570 PQVFSKLFSS 580 VTFEIVEESK 590 APRTRAVRNV 600 RRHACSSIIK 610 MCRDYPQLVL 620 PNFDMLYDHV 630 KQLLSNELLL 640 TQMEKCALME 650 ALVLISNQFK 660 NYERQKLFIE 670 ELMAPVASIW 680 LSEEMHRALS 690 DADAFLAFVG 700 ADQKSYDLVQ 710 EDPCGLNRAR 720 MSFCVYSILG 730 VVKRTSWPPD 740 LEEAKAGGFV 750 VGYTPTGNPI 760 FRNPCTEQVL 770 KLLDNLLALI 780 RTHNSLYAPE 790 MLAKLGEPFS 800 KALDMIDAEK 810 STILGLPQPL 820 LDLNDSPVYK 830 TILEKMQRFF 840 CTLYENCFHI 850 LGKAGPSMQQ 860 DFYTVEQLST 870 QLLSSAFVNL 880 DNLPDYRLRP 890 LLRVFVKPLV 900 LACTPEYYES 910 LVSPIVGPLF 920 TYLHMRLSQK 930 WQIINQRSML 940 CEDETTDENP 950 ESQEMLEEQL 960 VRMLTREVVD 970 LITVCCVSKK 980 GADHTATPAA 990 DGEDEEMMAT 1000 EVATPATAEL 1010 TDLGKCLTKH 1020 EDVCTALLIL 1030 AFNSLAWKDT 1040 LSCQRTTTQL 1050 CWPLLKQVLS 1060 GTLLAEAVTW 1070 LFTSVLKGLQ 1080 THGQHDGCMA 1090 SLVHLAFQTY 1100 EALRPRYVEI 1110 RAVMEQIPDI 1120 QKESLDQFDC 1130 KLLNPSLQKA 1140 ADKRRKDQFK 1150 RLIAGCIGKP 1160 LGEQFRKEVH 1170 IKNLPSLFKK 1180 TKPTHDSDAL 1190 DNDEGGLATI FEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0031047 regulatory ncRNA-mediated gene silencing
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0031267 small GTPase binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.