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Overview

Uniprot IDA0A8W4F9I9
Protein NameE3 ubiquitin-protein ligase UHRF
Gene NameUHRF1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
369 ACRLCGGKQDPDKQL
545 AEQSCDQKLTNTNRA
605 NRYDGIYKVVRYWPE
71 NSLSRLTKVENLRRR

Function

Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications

Protein Sequence

10 MGCLSGPRSL 20 LAFWEFPGVQ 30 SLDNSKDDPC 40 MARLDSGSLL 50 LSAPAGIMWI 60 QVRTMDGKVA 70 HTVNSLSRLT 80 KVENLRRRIQ 90 EVFHVEPGLQ 100 RLFYRGKQME 110 DGHTLFDYDV 120 RLNDTIQLLV 130 RQSPISSKER 140 DSELSDTDSG 150 CCLGQSESDK 160 SSNSGEAANE 170 PEVKADEDTW 180 DETELGLYKA 190 GEYVDARDTN 200 MGAWFEAQVI 210 RVTKKTVAQD 220 RPCSSSSSSS 230 STLEDDVIYH 240 VKYEDYPENG 250 VVQLSSRDVR 260 ARARQILKWH 270 ELEVGQVVML 280 NYNTDSPKDR 290 GFWYDAEILR 300 KRETRTAREL 310 HANVRIGDDS 320 LNDCRIIFVD 330 EVFKIERPGE 340 GSPLVETPVR 350 RKSGPTCKHC 360 KDNPRKLCRM 370 CACRLCGGKQ 380 DPDKQLMCDE 390 CDMAFHMYCL 400 CPPLSSVPSE 410 AEWYCPECRI 420 DSSEVVQAGE 430 KLKESKKKAK 440 MASATSSSQR 450 DWGKGMACVG 460 RTKECTIVPS 470 NHYGPIPGIP 480 VGTMWRFRVQ 490 VSESGVHRPH 500 VAGIHGRSND 510 GAYSLVLAGG 520 YEDDVDHGNS 530 FTYTGSGGRD 540 LSGNKRTAEQ 550 SCDQKLTNTN 560 RALALNCFAP 570 INDRKGAEAK 580 DWRSGKPVRV 590 VRNVKGRKHS 600 KYAPVEGNRY 610 DGIYKVVRYW 620 PEKGKSGFLV 630 WRFLLRRDDV 640 EPGPWTKEGK 650 DRIKKLGLTM 660 QVSHALPAPL 670 ADCSPAGPRA 680 WALGVQPAGS 690 RGGKVSDGPS 700 RGAPKKTKVE 710 PYSLTAQQSS 720 LIKEDKSNTK 730 LWTEILKSLK 740 DGPKFLSKVE 750 ETFQCICCQE 760 LVFRPITTVC 770 QHNVCKDCLD 780 RSFKAQVFSC 790 PACRYNLGRH 800 STMQVNQPLQ 810 AVLSQLFPGY GNGR

Gene Ontology

Classification GO ID Description
Molecular Function GO:0008270 zinc ion binding
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006950 response to stress

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.