Search Results
Overview
| Uniprot ID | A0A8W4F9K1 |
|---|---|
| Protein Name | Steroid receptor RNA activator 1 |
| Gene Name | SRA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 178 | DCRGHTKKQVCDDIN |
| 205 | GKLSVPVKKRMALLV |
| 69 | RYVKPGNKERGWNDP |
Function
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis
Protein Sequence
10
MSPLGSWSRV
20
FTAPPSVSAQ
30
PSNLESARQP
40
ALLGACLSAL
50
PVPAPEVTCC
60
PAGRAEVEMA
70
ERYVKPGNKE
80
RGWNDPPQFS
90
YGLQTQAGGP
100
KRTPLTKRVA
110
PPQDGLPRVP
120
TSEMSPGAPA
130
VGHLPPSSKA
140
SRPPLGGSCP
150
PSSMEPTQCS
160
VVELEILLED
170
VLSPLERALE
180
DCRGHTKKQV
190
CDDINRRLAL
200
LQEQWAGGKL
210
SVPVKKRMAL
220
LVQELSSHQW
230
DAADDIHRSL
240
MVDHVTEVSQ
250
WMVGVKRLIA
260
EKRSLSSEEE
270
ANEGKSTAAA
280
EQNQTLPGIP
HTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0002153 | steroid receptor RNA activator RNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045662 | negative regulation of myoblast differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.