Search Results
Overview
| Uniprot ID | A0A8W4FA00 |
|---|---|
| Protein Name | Membrane-associated progesterone receptor component 1 |
| Gene Name | PGRMC2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 154 | GKVFDVTKGSKFYGP |
| 215 | WEMQFKEKYDYVGRL |
Function
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization
Protein Sequence
10
MGGAREVGAG
20
RGRGGGGRRW
30
RAVMAAGDGD
40
VKLGTLGSGS
50
ESSSDGSSES
60
PGGAGEAAEG
70
GGWATAALAL
80
LTGGEMLLNV
90
ALVALVLLGA
100
YRLWVRWGRR
110
GLGAGAGAGE
120
ESPAASLPRM
130
KKRDFSLEQL
140
RQYDGSRTPR
150
ILLAVNGKVF
160
DVTKGSKFYG
170
PAGPYGIFAG
180
RDASRGLATF
190
CLDKDALKDE
200
YDDLSDLNAV
210
QMESVREWEM
220
QFKEKYDYVG
230
RLLKPGEEPS
240
EYTDEEDTKD
HNKQD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0030868 | smooth endoplasmic reticulum membrane |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0015232 | heme transmembrane transporter activity |
| Biological Process | GO:0060612 | adipose tissue development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.