Search Results
Overview
| Uniprot ID | A0A8W4FA29 |
|---|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 C |
| Gene Name | UBE2C |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 92 | CLDILKDKWSALYDV |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Protein Sequence
10
MASQNRDPAA
20
ASFAAARKGA
30
EPSGGAARGP
40
VGKRLQQELM
50
TLMVYEDLRY
60
KLSLEFPSGY
70
PYNAPTVKFL
80
TPCYHPNVDT
90
QGNICLDILK
100
DKWSALYDVR
110
TILLSIQSLL
120
GEPNIDSPLN
130
THAAELWKNP
140
TAFKKYLQET
150
YSKQVSSQEP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Biological Process | GO:0051301 | cell division |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.