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Overview

Uniprot IDA0A8W4FB57
Protein NamePolypyrimidine tract-binding protein 3
Gene NamePTBP3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
425 SGQRLYGKVLRATLS
49 GNDNKKFKGDRPPCS
505 TEAGCSVKAFKFFQK
508 GCSVKAFKFFQKDRK

Function

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform

Protein Sequence

10 MVRGAGGGGG 20 GARGRGSDEL 30 LSSGIINGPF 40 TMNSSTPSTA 50 NGNDNKKFKG 60 DRPPCSPSRV 70 LHLRKIPSDV 80 TEAEVISLGL 90 PFGKVTNLLM 100 LKGKSQAFLE 110 MASEEAAVTM 120 VNYYTPVTPH 130 LRSQPVFIQY 140 SNHRELKTDN 150 LPNQARAQAA 160 LQAVSAVQSG 170 SLGLPGAPTN 180 EGTILPGQSP 190 VLRIIIENLF 200 YPVTLEVLHQ 210 IFSKFGTVLK 220 IITFTKNNQF 230 QALLQYADPL 240 NAHYAKMALD 250 GQNIYNACCT 260 LRIDFSKLTS 270 LNVKYNNDKS 280 RDFTRLDLPT 290 GDGQPSLEPP 300 MAAAFGAPGI 310 ISSPYAGAAG 320 FAPAIGFPQA 330 TGLSVPAGLG 340 PGALGPLAIT 350 SSAVTGRMAM 360 PGTGGIPGNS 370 VLLVTNLNPD 380 LVTPHGLFIL 390 FGVYGDVHRV 400 KIMFNKKENA 410 LVQMADANQA 420 QLAMNHLSGQ 430 RLYGKVLRAT 440 LSKHQAVQLP 450 REGQEDQGLT 460 KDFSNSPLHR 470 FKKPGSKNFQ 480 NIFPPSATLH 490 LSNIPPSVTV 500 DDLKNLFTEA 510 GCSVKAFKFF 520 QKDRKMALIQ 530 LGSVEEAIQA 540 LIELHNHDLG 550 ENHHLRVSFS KSTI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0043249 erythrocyte maturation
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.