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Overview

Uniprot IDA0A8W4FB66
Protein NameProteasome assembly chaperone 1
Gene NamePSMG1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
159 KVFGSCPKKNMQVTV
160 VFGSCPKKNMQVTVL
193 TPFLRALKTQNFREA

Function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization

Protein Sequence

10 MAATFFGEVV 20 KAPCRAGTED 30 EEEEEEGRRE 40 TPEDREVRRQ 50 LARKREVRLL 60 RRQTKTSLDV 70 SLLEKYPCSK 80 FIIAIGNNAV 90 AFLSSFVMNS 100 GVWEEVGCAK 110 LWNEWCRTTD 120 TTHLSPAEAF 130 CVFYHLKSNP 140 SVLLCQCSCY 150 VAEDQQFQWL 160 EKVFGSCPKK 170 NMQVTVLTCR 180 HVTDFKTSES 190 TSSLHTPFLR 200 ALKTQNFREA 210 PCCSLLEQPN 220 IVHDLPAAVL 230 SYCQVWKIPA 240 VLYLCYTDVM 250 KLDLITVEAF 260 KPVLSSRSLK 270 GLVKNPRCLC 280 GKMVSLFRKF L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Biological Process GO:0043248 proteasome assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.