Search Results
Overview
| Uniprot ID | A0A8W4FBB0 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 213 | RDYPLASKDAKKQLL |
| 217 | LASKDAKKQLLCGAA |
| 437 | FSEADKIKVAQGVSG |
| 449 | VSGAVQDKGSIHKFV |
| 510 | HSLHSYEKRLF**** |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MADYLISGGT
20
SYVPDDGLTA
30
QQLFNCGDGL
40
TYNDFLILPG
50
YIDFTADQVD
60
LTSALTKKIT
70
LKTPLVSSPM
80
DTVTEAGMAI
90
AMAKYEQGFI
100
TDPVVLSPKD
110
RVRDVFEAKA
120
QHGFCGIPIT
130
DTGRMGSRLV
140
GIISSRDIDF
150
LKEEEHDRFL
160
EEIMTKREDL
170
VVAPAGITLK
180
EANEILQRSK
190
KGKLPIVNED
200
DELVAIIART
210
DLKKNRDYPL
220
ASKDAKKQLL
230
CGAAIGTHED
240
DKYRLDLLAQ
250
AGVDVVVLDS
260
SQGNSIFQIN
270
MIKYIKEKYP
280
SLQVIGGNVV
290
TAAQAKNLID
300
AGVDALRVGM
310
GSGSICITQE
320
AAPKIPPDIK
330
SHSPKCPSTV
340
TGCYMLACGR
350
PQATAVYKVS
360
EYARRFGVPV
370
IADGGIQNVG
380
HIAKALALGA
390
STVMMGSLLA
400
ATTEAPGEYF
410
FSDGIRLKKY
420
RGMGSLDAMD
430
KHLSSQNRYF
440
SEADKIKVAQ
450
GVSGAVQDKG
460
SIHKFVPYLI
470
AGIQHSCQDI
480
GAKSLTQVRA
490
MMYSGELKFE
500
KRTSSAQVEG
510
GVHSLHSYEK
RLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006177 | GMP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.