Overview
| Uniprot ID | A0A8W4FBM9 |
|---|
| Protein Name | Nucleoporin SEH1 |
|---|
| Gene Name | SEH1L |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 292 |
DVRIFTLKPVRKELT |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
MFVARSIAAD
20
HKDLIHDVSF
30
DFHGRRMATC
40
SSDQSVKVWD
50
KSESGDWHCT
60
ASWKGRVHGI
70
WRFRARGPVG
80
AVAAGLCHSN
90
VGSEPSSLRP
100
TPQLTTHSGS
110
VWRVTWAHPE
120
FGQVLASCSF
130
DRTAAVWEEI
140
VGESNDKLRG
150
QSHWVKRTTL
160
VDSRTSVTDV
170
KFAPKHMGLM
180
LATCSADGIV
190
RIYEAPDVMN
200
LSQWSLQHEV
210
SCKLSCSCIS
220
WNPSSSRAHP
230
PMIAVGSDDG
240
SPNAMAKVQI
250
FEYNENTRKY
260
AKAETLMTVT
270
DPVHDIAFAP
280
NLGRSFHILA
290
IATKDVRIFT
300
LKPVRKELTS
310
SGGPTKFEIQ
320
VVAQFDNHNS
330
QVWRVSWNIT
340
GTVLASSGDD
350
GCVRLWKANY
360
MDNWKCTGIL
370
KGNGSPVSGS
380
SQQGNANPSL
390
GSNTPNLQHS
LNGSSASR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.