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Overview

Uniprot IDA0A8W4FC34
Protein NameNucleolin
Gene NameNCL
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
10 KNQGDPKKMAPPPKE
103 KAVATPGKKGATPAK
110 KKGATPAKALVATSG
118 ALVATSGKKGAAAPA
119 LVATSGKKGAAAPAK
126 KGAAAPAKGAKNGKN
221 KGKKAPAKAVPVKAK
226 PAKAVPVKAKSTAED
295 KKEMAKQKAAPEAKK
3 *****AGKNQGDPKK
301 QKAAPEAKKQKVEAT
331 SKSASELKTGISDVF
384 KVFGNEIKLEKPKGK
405 DARTLLAKNLPYKVT
410 LAKNLPYKVTQDELK
451 KTEADAEKTLEEKQG
456 AEKTLEEKQGTEIDG
484 NQDFRGGKNSTWSGE
49 IPQKKGKKATPTPAK
552 EALNSCNKREIEGRA
56 KATPTPAKKVMVSPT
57 ATPTPAKKVMVSPTK
64 KVMVSPTKKVAAATP
65 VMVSPTKKVAAATPA
653 KVTLDWAKPKGEGGF
73 VAAATPAKKAVVTPG
74 AAATPAKKAVVTPGK
81 KAVVTPGKKAAATPA
82 AVVTPGKKAAATPAK
89 KAAATPAKKTVTPAK
90 AAATPAKKTVTPAKA
96 KKTVTPAKAVATPGK

Function

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats

Protein Sequence

10 AGKNQGDPKK 20 MAPPPKEVEE 30 DSEDEEMSDD 40 EEDDSSGEEV 50 IIPQKKGKKA 60 TPTPAKKVMV 70 SPTKKVAAAT 80 PAKKAVVTPG 90 KKAAATPAKK 100 TVTPAKAVAT 110 PGKKGATPAK 120 ALVATSGKKG 130 AAAPAKGAKN 140 GKNAKKEDSD 150 EEDEDDSEED 160 EEDEEEDEDD 170 FEPAVVKGAA 180 AAAAPASDDE 190 EEEEDEDEDE 200 DEDEDDEEEE 210 DDSEEEAMET 220 VPAKGKKAPA 230 KAVPVKAKST 240 AEDEDEEEDE 250 EDEEDEEDDD 260 EDEDEEEDEE 270 EEEDEEDEDE 280 DEEEEEEEPV 290 KEAPGKRKKE 300 MAKQKAAPEA 310 KKQKVEATEP 320 TTSFNLFVGN 330 LNFSKSASEL 340 KTGISDVFAK 350 NDLAVVDVRI 360 GVSRKFGYVD 370 FESAEDLEKA 380 LELTGLKVFG 390 NEIKLEKPKG 400 KDSKKDRDAR 410 TLLAKNLPYK 420 VTQDELKEVF 430 EDAVEIRLVS 440 KDGKSKGIAY 450 IEFKTEADAE 460 KTLEEKQGTE 470 IDGRSISLYY 480 TGEKGQNQDF 490 RGGKNSTWSG 500 ESKTLVLSNL 510 AYSATEETLQ 520 EVFEKATFIK 530 VPQNQNGKSK 540 GYAFIEFASF 550 EDAKEALNSC 560 NKREIEGRAI 570 RLELQGPRGS 580 PNARSQPSKT 590 LFVKGLSEET 600 TEETLKESFD 610 GSIRARIVTD 620 RETGSSKGFG 630 FVDFNSEEDA 640 KAAKEAMEDG 650 EIDGNKVTLD 660 WAKPKGEGGF 670 GGRGGGRGGF 680 GGRGGGRGGR 690 GGFGGRGRGG 700 FGGRGGFRGG 710 RGGGGGDHKP QGKKTKFE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005694 chromosome
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0044547 DNA topoisomerase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0043560 insulin receptor substrate binding
Molecular Function GO:0048027 mRNA 5'-UTR binding
Molecular Function GO:0042731 PH domain binding
Molecular Function GO:0042162 telomeric DNA binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0017148 negative regulation of translation
Biological Process GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.