Search Results
Overview
| Uniprot ID | A0A8W4FC46 |
|---|---|
| Protein Name | Protein disulfide-isomerase A6 |
| Gene Name | PDIA6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | IKIFGSNKNRPEDYQ |
| 144 | GGGYSSGKQGRSEGS |
| 154 | RSEGSGKKDVIELTD |
| 202 | AAAATEVKEQTKGKV |
| 210 | EQTKGKVKLAAVDAT |
| 235 | IRGFPTIKIFQKGES |
| 239 | PTIKIFQKGESPVDY |
| 362 | AINARKMKFALLKGS |
| 60 | QRLTPEWKKVATALK |
| 61 | RLTPEWKKVATALKD |
| 67 | KKVATALKDVVKVGA |
| 71 | TALKDVVKVGAVDAD |
| 79 | VGAVDADKHQSLGGQ |
Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
Protein Sequence
10
VRRDCTLFVA
20
VNGLYSSSDD
30
VIELTPSNFN
40
REVIQSDSLW
50
LVEFYAPWCG
60
HCQRLTPEWK
70
KVATALKDVV
80
KVGAVDADKH
90
QSLGGQYGVQ
100
GFPTIKIFGS
110
NKNRPEDYQG
120
GRTGEAIVDA
130
ALSALRQLVK
140
DRLGGRGGGY
150
SSGKQGRSEG
160
SGKKDVIELT
170
DDTFDKNVLD
180
SEDVWMVEFY
190
APWCGHCKNL
200
EPEWAAAATE
210
VKEQTKGKVK
220
LAAVDATVNQ
230
VLASRYGIRG
240
FPTIKIFQKG
250
ESPVDYDGGR
260
TRSDIVTRAL
270
DLFSDNAPPP
280
ELLEIISEDV
290
AKKSCEEHQL
300
CVVAVLPHIL
310
DTGAAGRNSY
320
LEVLLKLADK
330
YKKKMWGWLW
340
TEAGAQTELE
350
HALGIGGFGY
360
PAMAAINARK
370
MKFALLKGSF
380
SEQGINEFLR
390
ELSFGRGSTA
400
PVGGGAFPAI
410
STREPWDGKD
420
GELPVEDDID
430
LSDVELDDLE
KDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.