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Overview

Uniprot IDA0A8W4FC88
Protein NameIntegrin alpha-6
Gene NameITGA6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
144 KRQHVNTKQESRDIF
679 SNLKLEYKFCTREGN
915 VESKGLDKVACQPQR

Function

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling

Protein Sequence

10 MAAAGRLWLL 20 YLSAGLLPRL 30 GAAFNLDTRE 40 DNVIEKTGDS 50 GSLFGFSLAM 60 HRQLEPEEKR 70 LVLVGAPRAV 80 ALPLQKANRT 90 GGLYSCDITS 100 RGPCTRIEFD 110 NDADPSSESK 120 EDQWMGVTVQ 130 SQGPGGKVVT 140 CAHRYEKRQH 150 VNTKQESRDI 160 FGRCYVLSQN 170 LRIEDYMDGG 180 DWSFCDGRLR 190 GHEKFGSCQQ 200 GVAATFTKDY 210 HYIVFGAPGT 220 YNWKGIVRVE 230 QKNNTFFDMN 240 IFEDGPYEVG 250 GETDNDESLV 260 PVPANSYLGL 270 LFLTSVSYTD 280 PDQFVYKTQP 290 REQPDTFPDV 300 MMNSYLGFSL 310 DSGKGIVSKD 320 EITFVSGAPR 330 ANHSGAVVLL 340 KRDLKSAHLL 350 PEHIFDGEGL 360 ASSFGYDVAV 370 VDLNSDGWQD 380 IVIGAPQYFD 390 RSGEVGGAVY 400 VYMNQQGRWK 410 NVKPIRLNGT 420 KDSMFGVAVK 430 NIGDINQDGY 440 PDIAVGAPYD 450 GKGKVFIYHG 460 SANGINTKPT 470 QVLEGKSPSF 480 GYSIAGNMDL 490 DRNWYPDVAV 500 GSLSDSVTIF 510 RSRPVINIQQ 520 TITVTPNRID 530 LRQKTSCGAP 540 SGICLKVKAC 550 FEYTTKPAND 560 DPSITIVGTL 570 EAEKERRKSG 580 LSSRVQFRNQ 590 GSEPKYTQEL 600 TLHRQKQKAC 610 MEETLWLQEN 620 IRDKLRPIPI 630 TASVEIQEPS 640 TRRRVNSLPE 650 VLPILNSNEP 660 KSVHTDVHFL 670 KEGCGADNIC 680 NSNLKLEYKF 690 CTREGNQDKF 700 SYLPIQKGVP 710 ELVLKDQKDI 720 ALEITVTNSP 730 SDRNPTKDGD 740 DAHEAKLIAT 750 FPDTLTYSAY 760 RELRAFPEKQ 770 LSCVANQNGS 780 QADCELGNPF 790 KRNSSVTFYL 800 ILSTTEVTFD 810 TTDLDINLKL 820 ETTSNQDNLA 830 SITATAKVVI 840 ELLLSVSGVA 850 KPSQVYFGGT 860 VVGEQAMKSE 870 DEVGSLIEYE 880 FRVINLGKPL 890 KNLGTATLNI 900 QWPKEISNGK 910 WLLYLVKVES 920 KGLDKVACQP 930 QREINSLQLK 940 ESHNSRRKRE 950 IAERQRDDGR 960 KFSLFAERKY 970 QTLNCSVNVN 980 CVNIRCPLQG 990 LDSKASVVLR 1000 SRLWNSTFLE 1010 EYSKMNYLDI 1020 LVRASIDMTA 1030 ATENIKLPNA 1040 GTQVRVTVFP 1050 SKTAAQYSGV 1060 PWWIILVAIL 1070 AGILMLALLV 1080 FLLWKCGFFK 1090 RSRYDDSVPR 1100 YHAVRIRKEE 1110 REIKDEKYND 1120 NLEKKQWITR WNENESYS

Gene Ontology

Classification GO ID Description
Biological Process GO:0043589 skin morphogenesis
Cellular Component GO:0009986 cell surface
Cellular Component GO:0034675 integrin alpha6-beta1 complex
Cellular Component GO:0034676 integrin alpha6-beta4 complex
Molecular Function GO:0031994 insulin-like growth factor I binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0038132 neuregulin binding
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0010668 ectodermal cell differentiation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0035878 nail development
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.