Search Results

Overview

Uniprot ID	A0A8W4FCG4
Protein Name	E3 ubiquitin-protein ligase ZFP91
Gene Name	ZFP91
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
125	PRLLCTEKVSTSKDP
330	YQHLLKKKYVCPHPS

Function

DNA-binding transcription factor. Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis

Protein Sequence

10 MPGETEEPRP 20 PEQQDQEGGE 30 AAAAAKAAPE 40 EPQQQPPEEA 50 AVAAPAGTTT 60 SRVLRGGRDR 70 GRAAAAAAAA 80 AAAAVSRRRK 90 AEYPRRRRSS 100 PSARPPDAPG 110 QQSQAAKPPS 120 PAQGKKSPRL 130 LCTEKVSTSK 140 DPKEEKEEDD 150 SALPQEASIA 160 ATRPSRGWRS 170 SSRTSVSRHR 180 DTENTRSSRS 190 KTGSLQLICK 200 SEPNTDQLDY 210 DVAEEHQSPG 220 GISDEEEEEE 230 EEMLISEEEI 240 PFKDDPRDET 250 YKPHLERETP 260 KPRRKSGKVK 270 EEKEKKEIKV 280 EVEVEVKEEE 290 NEIREDEEPP 300 RKKKPPIQYV 310 RCEMEGCGTV 320 LAHPRYLQHH 330 IKYQHLLKKK 340 YVCPHPSCGR 350 LFRLQKQLLR 360 HAKHHTDQRD 370 YICEYCARAF 380 KSSHNLAVHR 390 MIHTGEKPLQ 400 CEICGFTCRQ 410 KASLNWHMKK 420 HDADSFYQFS 430 CNICGKKFEK 440 KDSVVAHKAK 450 SHPEVLIAEA 460 LAANAGALIT 470 STDILGTNPE 480 SLTQPADGQG 490 LPLLPEPLGN 500 STSGECLLLE 510 AEGMSKSYCS 520 GTERVSLMAD 530 GKLFVGSGSS 540 GGTEGLVMNS 550 DILGATTEVL IEDSDSTGP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0060255	regulation of macromolecule metabolic process
Biological Process	GO:0080090	regulation of primary metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.