Search Results
Overview
| Uniprot ID | A0A8W4FCN0 |
|---|---|
| Protein Name | Phosphoinositide phospholipase C |
| Gene Name | PLCD1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 335 | AYIRALCKGCRCLEL |
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Binds phosphatidylinositol 4,5-bisphosphate
Protein Sequence
10
MDSGRDFLTL
20
HGLQDDKDLQ
30
ALLKGGQLLK
40
VKSNSWRRER
50
FYKLQEDCKT
60
IWQESRKVMR
70
TPESQLFSIE
80
DIQEVRMGHR
90
TEGLEKFARD
100
VPEDRCFSIV
110
FKDQRNTLDL
120
IAPSPADAQH
130
WVLGLRKIIH
140
HSGSMDQRQK
150
LQHWIHSCLR
160
KADKNKDNKM
170
SFKEVQNFLK
180
ELNIQVDDSY
190
ARKIFRECDH
200
SQTDSLEDEE
210
IETFYKMLTQ
220
RKEIDRIFEE
230
AAGSEEALSV
240
DQLVAFLQHQ
250
QQEEAAGPAL
260
ALSLIERYEP
270
SETAKAQRQM
280
TKDGFLMYLL
290
SADGSAFNLA
300
HRRVYQDMGQ
310
PLSHYLVSSS
320
HNTYLLEDQL
330
TGPSSTEAYI
340
RALCKGCRCL
350
ELDCWDGPNL
360
EPIIYHGYTF
370
TSKILFCDVL
380
RAIRDYAFKA
390
SSYPVILSLE
400
NHCSLEQQRV
410
MARHLRALLG
420
PMLDRPLDGV
430
TTSLPSPEQL
440
KGKILLKGKK
450
LGGLFPPGGE
460
GSPEATVVSD
470
EDEAAEMEDE
480
AVRSRVQHKP
490
TEDKLRLVKE
500
LSDMVIYCKS
510
VHFRGFPSPG
520
TPGQAFYEMA
530
SFSENRALRL
540
LQESGNSFVR
550
HNVNHSRIYP
560
AGWRTDSSNY
570
NPVEMWNSGC
580
QIVALNFQTP
590
GPEMDVYQGR
600
FQDNGACGYV
610
LKPAFLRDPN
620
SAFNSRALAQ
630
GPWWARKRLS
640
VRVISGQQLP
650
KVNKNKNSIV
660
DPKVTVEIHG
670
VGRDVASRQT
680
AVVTNNGFNP
690
WWDTEFEFEV
700
VVPELALVRF
710
VVEDYDASSK
720
NDFIGQSTIP
730
LSSLKQGYRH
740
VHLLSKNGDQ
750
YPSATLFVKV
ALWD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0032794 | GTPase activating protein binding |
| Molecular Function | GO:0070300 | phosphatidic acid binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0004435 | phosphatidylinositol-4,5-bisphosphate phospholipase C activity |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0046488 | phosphatidylinositol metabolic process |
| Biological Process | GO:0141212 | phospholipase C/protein kinase C signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.