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Overview

Uniprot IDA0A8W4FCQ6
Protein NameDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Gene NameRPN2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
311 TVKLEHAKSVASRAT
401 TRVTYPAKAKGAFIA
442 FVRLHNQKTGQEVVF
70 AQVPDEKKACTFIKS

Function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity

Protein Sequence

10 ISPQGSSTVL 20 LLALTIIASA 30 QALTPTHYLT 40 KHDVERLKAS 50 LDRPFTSLES 60 AFYSIVGLSS 70 LGAQVPDEKK 80 ACTFIKSNLD 90 PSNVDSLFYT 100 AQSSQALSGC 110 EISISNETKD 120 LLLAAVSEDS 130 SVTQIYHAVA 140 ALSGFGLPLA 150 SQEALGALTA 160 RLSKEETVLA 170 TVQALQTASY 180 LSQQADLRSI 190 VEEIEDLVAR 200 LDELGGVYLQ 210 FEEGLETTAL 220 FVAATYKLMD 230 HVGTEPSIKE 240 DQVIQLMNTI 250 FSKKNFESLP 260 EAFSVASAAA 270 ALSQNRYHVP 280 VVVVPEGSPS 290 DTQEQAFLRL 300 QVTNVLSQPL 310 TQATVKLEHA 320 KSVASRATVL 330 QKTSFTPVGD 340 VFELNFVNVK 350 FSSGYYDFSV 360 KVEGDNRYIA 370 NTVELRVKIS 380 TEVGITNVDL 390 STVDKDQSIA 400 PKTTRVTYPA 410 KAKGAFIADS 420 HQNFALFFQL 430 VDVNTGAELT 440 PHQTFVRLHN 450 QKTGQEVVFV 460 AEPDSKNVYR 470 FELDTSERKI 480 EFDSASGTYT 490 LYLIIGDATL 500 KNPIHWNVAD 510 VVIRFPEEDA 520 PSTVLSKNLF 530 TAKQEIQHLF 540 REPEKRPPTV 550 VSNTFTALIL 560 SPLLLLFALW 570 IRIGANISNF 580 TFAPSTIIFH 590 LGHAAMLGLM 600 YVYWTQLNMF 610 QTLKYLAILG 620 SVTFLAGNRM 630 LAQQAIKRSF 640 LNQKRALVIS 650 FKYIKTTTVY ALTH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0160226 oligosaccharyltransferase complex A
Cellular Component GO:0160227 oligosaccharyltransferase complex B
Biological Process GO:0006487 protein N-linked glycosylation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.