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Overview

Uniprot IDA0A8W4FCW7
Protein NameIntegrin alpha-6
Gene NameITGA6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
586 SNLKLEYKFCTREGN
822 VESKGLDKVACQPQR
95 KRQHVNTKQESRDIF

Function

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling

Protein Sequence

10 MHRQLEPEEK 20 RLVLVGAPRA 30 VALPLQKANR 40 TGGLYSCDIT 50 SRGPCTRIEF 60 DNDADPSSES 70 KEDQWMGVTV 80 QSQGPGGKVV 90 TCAHRYEKRQ 100 HVNTKQESRD 110 IFGRCYVLSQ 120 NLRIEDYMDG 130 GDWSFCDGRL 140 RGHEKFGSCQ 150 QGVAATFTKD 160 YHYIVFGAPG 170 TYNWKGLLFL 180 TSVSYTDPDQ 190 FVYKTQPREQ 200 PDTFPDVMMN 210 SYLGFSLDSG 220 KGIVSKDEIT 230 FVSGAPRANH 240 SGAVVLLKRD 250 LKSAHLLPEH 260 IFDGEGLASS 270 FGYDVAVVDL 280 NSDGWQDIVI 290 GAPQYFDRSG 300 EVGGAVYVYM 310 NQQGRWKNVK 320 PIRLNGTKDS 330 MFGVAVKNIG 340 DINQDGYPDI 350 AVGAPYDGKG 360 KVFIYHGSAN 370 GINTKPTQVL 380 EGKSPSFGYS 390 IAGNMDLDRN 400 WYPDVAVGSL 410 SDSVTIFRSR 420 PVINIQQTIT 430 VTPNRIDLRQ 440 KTSCGAPSGI 450 CLKVKACFEY 460 TTKPANDDPS 470 ITIVGTLEAE 480 KERRKSGLSS 490 RVQFRNQGSE 500 PKYTQELTLH 510 RQKQKACMEE 520 TLWLQENIRD 530 KLRPIPITAS 540 VEIQEPSTRR 550 RVNSLPEVLP 560 ILNSNEPKSV 570 HTDVHFLKEG 580 CGADNICNSN 590 LKLEYKFCTR 600 EGNQDKFSYL 610 PIQKGVPELV 620 LKDQKDIALE 630 ITVTNSPSDR 640 NPTKDGDDAH 650 EAKLIATFPD 660 TLTYSAYREL 670 RAFPEKQLSC 680 VANQNGSQAD 690 CELGNPFKRN 700 SSVTFYLILS 710 TTEVTFDTTD 720 LDINLKLETT 730 SNQDNLASIT 740 ATAKVVIELL 750 LSVSGVAKPS 760 QVYFGGTVVG 770 EQAMKSEDEV 780 GSLIEYEFRV 790 INLGKPLKNL 800 GTATLNIQWP 810 KEISNGKWLL 820 YLVKVESKGL 830 DKVACQPQRE 840 INSLQLKESH 850 NSRRKREIAE 860 RQRDDGRKFS 870 LFAERKYQTL 880 NCSVNVNCVN 890 IRCPLQGLDS 900 KASVVLRSRL 910 WNSTFLEEYS 920 KMNYLDILVR 930 ASIDMTAATE 940 NIKLPNAGTQ 950 VRVTVFPSKT 960 AAQYSGVPWW 970 IILVAILAGI 980 LMLALLVFLL 990 WKCGFFKRNK 1000 KDHYDATYHK 1010 AEIHAQPSDK ERLTSDA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0008305 integrin complex
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.