Search Results
Overview
| Uniprot ID | A0A8W4FDJ8 |
|---|---|
| Protein Name | tRNA (guanine-N(7)-)-methyltransferase |
| Gene Name | METTL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | AEASQPQKRYYRQRA |
Function
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
Protein Sequence
10
MAGAETRDAA
20
EAEASQPQKR
30
YYRQRAHSNP
40
MADHTLCYPV
50
KPEDMDWSEL
60
YPEFFTPPTQ
70
NQSHDDPKDE
80
KEKRAQAQVE
90
FADIGCGYGG
100
LLVALSPLFP
110
DTLMLGLEIR
120
VKVSDYVQDR
130
IRALRAAPGG
140
GFQNIACLRS
150
NAMKHLPNFF
160
RKGQLTKMFF
170
LFPDPHFKRT
180
KHKWRIISPT
190
LLAEYAYVLS
200
VGGLVYTITD
210
VLELHDWMCT
220
HFEGHPLFER
230
VPLEELSEDP
240
IVGHLGTSTE
250
EGKKVLRNGG
260
KNFPAIFRRI
270
QDPTLQAVTP
SPTPPGH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0000049 | tRNA binding |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0106143 | tRNA (m7G46) methyltransferase complex |
| Cellular Component | GO:0043527 | tRNA methyltransferase complex |
| Molecular Function | GO:0160090 | internal mRNA (guanine-N7-)-methyltransferase activity |
| Molecular Function | GO:0008176 | tRNA (guanine(46)-N7)-methyltransferase activity |
| Biological Process | GO:0033554 | cellular response to stress |
| Biological Process | GO:0036265 | RNA (guanine-N7)-methylation |
| Biological Process | GO:0030488 | tRNA methylation |
| Biological Process | GO:0036416 | tRNA stabilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.