Overview
| Uniprot ID | A0A8W4FDY5 |
|---|
| Protein Name | RNA-binding protein 33 |
|---|
| Gene Name | - |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 82 |
GSKVRVIKLSGGQGG |
Function
RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation
Protein Sequence
10
MKSLKPLRQA
20
RSIPPCPAQH
30
KVLQVKPADG
40
EGLPPPSQTA
50
RVASLQGRPP
60
EAKPGAKRTV
70
MHRASSGGGD
80
GPHIGSKVRV
90
IKLSGGQGGE
100
SDGCYHPEGQ
110
PQRLPPSPEV
120
RPQPARKVTL
130
TKGALPQPQH
140
PPVAAHVHSA
150
GPPAIKSIQG
160
IHPPKKVIMH
170
GRGRGMAGAM
180
GRGRLMPNKQ
190
NLRVVECKPQ
200
PCVVSVEGLS
210
SSTTDAQLKS
220
LLVSVGPIQS
230
LQMLPQQRKA
240
IAKFKEPAHA
250
LAFQQKFHRH
260
MIDLSHINVA
LIVE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0051028 |
mRNA transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.