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Overview

Uniprot IDA0A8W4FEY2
Protein NamesnRNA-activating protein complex subunit 4
Gene NameSNAPC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
306 AQEVDRLKAIAAKHG

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box

Protein Sequence

10 MDVDAEREKI 20 SKEIKELERI 30 LDPGSSGIND 40 DVSESSLDSD 50 SEAESLPDDD 60 ADATGPLLSE 70 DERWGDASND 80 EDDAKERALP 90 EDPETCLQLN 100 MVYQEVVREK 110 LAEVSLLLAQ 120 NREQQEEVSW 130 ALAGSGGRRV 140 KDGRSPPARL 150 YVGHFMKPYF 160 KDKVTGAGPP 170 ANEDTREKAA 180 QGVKAFEELL 190 VTKWKSWEKA 200 LLRKAVVSDR 210 LQRLLQPKLL 220 KLEYLQQKQS 230 RATSDAERQA 240 LEKQVREAEK 250 EVQDISQLPE 260 EALLGHRLDS 270 HDWEKIANVN 280 FEGGRSAEET 290 RKFWQNHEHP 300 SINKQEWSAQ 310 EVDRLKAIAA 320 KHGHLRWQEI 330 AEELGTRRSA 340 FQCLQKYQQH 350 NAALKRREWT 360 QEEDRMLTQL 370 VQAMGVGSHI 380 PYRRIAYYME 390 GRDSTQLIYR 400 WTKSLDPALK 410 KGLWAPEEDA 420 KLLQAVAKYG 430 EQDWFKIREE 440 VPGRSDAQCR 450 DRYLRRLRLS 460 LKKGRWSAQE 470 EERLLELIGK 480 HGVGHWAKIA 490 SELPHRTDSQ 500 CLSKWKIMSR 510 GRRRRRPLRR 520 VCWSSSSEDS 530 EDSGDSGGSS 540 SSSSSSEDVE 550 PEGAPEARAD 560 GPAPPSAQHP 570 VPDMDLWVPT 580 RQSARVPWGV 590 GPGAWPGHRS 600 ASPRPPEGSD 610 VAPGEEAGRA 620 QAPSETPSAS 630 LRGGGCPRSA 640 DARPSGSEGL 650 ADEGPRRPLT 660 VPLETVLRVL 670 RTNTAVPFCP 680 QKEKLRRPRL 690 LGSPLGPSPS 700 DGSVARPRVQ 710 PRWRRRHALQ 720 RRLLERQLLM 730 AVSPWVGDVT 740 LPCAPWRPAV 750 LASQDGLGRA 760 ACHRGQAVPP 770 VLQLFRIDTA 780 GCMEVVRERR 790 AQPPALPSGG 800 RVSLHSFLSQ 810 VPSSARNSPG 820 HLFQNGSARG 830 AAKKSASHSG 840 GGGPQSAPAP 850 SGPRPKPKTV 860 SELLREKRLR 870 EARARKAAQG 880 PAVLPPQGLL 890 SSPAILQPLP 900 PQQLPVSGAV 910 LSGPGGPAVA 920 SPGAPGPWAS 930 AKEGPPSLHA 940 LALAPASMAA 950 GVTPAAPRAP 960 ALGPSQVPAS 970 CHLSSLGQSQ 980 APATSRKQGL 990 PEAPPFLPAA 1000 PSPIQLPVQP 1010 RSLTPALAAH 1020 TGASHVVAST 1030 PLPVTWVLTA 1040 QGLLPVPAVV 1050 GLPRPAGPPD 1060 PEGLSGTPPP 1070 SLTETRAGRG 1080 PKQPPAHVSV 1090 GPDPPAKTPP 1100 TAQSPAEGDG 1110 DVAHGPGGPS 1120 CPGEAQVAGE 1130 ASVPRTLSPA 1140 KPLADHPEAE 1150 PCGSSQLPLP 1160 GGLSPGGAPT 1170 RHQGLERPPP 1180 PWPGPEKGAP 1190 DLRLLSQESE 1200 AAVRGWLTGQ 1210 RGVCVPPLAS 1220 RLPYQPPTLC 1230 SLRALSGLLL 1240 HKKALEHRAA 1250 SLVPSGAAGA 1260 QQAPLGQVRE 1270 RLQSSPAYLL 1280 LKARFLAAFA 1290 LPALLATLPP 1300 HGVPTTLSAA 1310 AGVDSESDDD 1320 SLDELELASR 1330 LPLAAPRCSL 1340 IPCPWWLEAP 1350 GEGSAAPGLD 1360 SDDLDILRTR 1370 HAWHARKRRR LV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0019185 snRNA-activating protein complex
Molecular Function GO:0016251 RNA polymerase II general transcription initiation factor activity
Molecular Function GO:0000995 RNA polymerase III general transcription initiation factor activity
Molecular Function GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
Biological Process GO:0042795 snRNA transcription by RNA polymerase II
Biological Process GO:0042796 snRNA transcription by RNA polymerase III

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.