Search Results
Overview
| Uniprot ID | A0A8W4FF91 |
|---|---|
| Protein Name | Twinfilin-1 |
| Gene Name | TWF1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | DVSLHGYKKYLLSQS |
| 20 | NGKYRLLKISIENEK |
| 27 | KISIENEKLVIGSCR |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles
Protein Sequence
10
SEDVKDIFAR
20
ARNGKYRLLK
30
ISIENEKLVI
40
GSCRQPSDSW
50
DKDYDSFVLP
60
MLEDKQPCYI
70
LFRLDSQNAQ
80
GYEWIFIAWS
90
PDHSHVRQKM
100
LYAATRATLK
110
KEFGGGHIKD
120
EVFGTVKEDV
130
SLHGYKKYLL
140
SQSSPAPLTA
150
AEEELRQIKI
160
NEVQTDVSVD
170
TKHQTLQGVA
180
FPISREAFQA
190
LEKLNNRQLN
200
YVQLEIDIKN
210
EVIILANTVN
220
TELKDLPKRI
230
PKDSARYHFF
240
LYKHSHEGDY
250
LDVFLSVCSL
260
GLSCSFMRER
270
MLYSSCKSPL
280
LEIVERQLQM
290
DVIRKIEIDN
300
GDELTADFLY
310
EEVHPKQHAH
320
KQSFAKPKGP
330
SGKRGIRRLI
340
RGPAETEATT
D
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.