Search Results

Overview

Uniprot IDA0A8W4FFH6
Protein NameEpiplakin
Gene NameEPPK1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
118 VGLELKEKLLAAERA
1397 LDERTSTKLTSTEDD
1646 FGRETYQKLLSAERA
26 AAVPKSVKATLGADA
390 PLFQAMKKELVDRPL

Function

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization

Protein Sequence

10 MNGHASSLDV 20 LVTNGTELAA 30 VPKSVKATLG 40 ADAPSEPQAQ 50 APASAQARGI 60 AGVYVEASGQ 70 AQSLYAAMKQ 80 GLLPFGLGLA 90 LLEAQAATGG 100 LVDPAQGRPL 110 LVSEALQQGL 120 VGLELKEKLL 130 AAERAVTGYP 140 DPYGGERLAL 150 FQAIGKEVVG 160 RALGWSWLEA 170 QLATGGLVDP 180 TRGGRVAPEL 190 ACQQGLLDQE 200 TWRGLTELGP 210 GSSAPGFLDP 220 NTLEELPYRE 230 LLGRCVRAPG 240 SGLALLPLKT 250 TFRTLSGAVS 260 LAELLEVGIL 270 DPGTARGLRE 280 GGLAVQDVSA 290 RAEVQRYLQG 300 TGGMAGVVLL 310 PAGHKKSFFQ 320 AAAEHLLPAG 330 ATLPLLEAQA 340 ATCTLVDPAT 350 GRQLCVDEAV 360 RAGLVGPELH 370 RQLLAAEQAV 380 MGYPDPFSGT 390 RIPLFQAMKK 400 ELVDRPLALR 410 LLDAQLATGG 420 LVCPTRRLRL 430 PLEAALRFGC 440 LDEETQQHLS 450 QAAGFSDPGT 460 QESLSYGQLL 470 ARCVTDPETG 480 LAFLPVSAGS 490 LGEEPRGPPF 500 IEHSTRQALR 510 AATATISVGK 520 FQGRPVSLWE 530 LLFSEAVPVE 540 QRITLTQQHK 550 DGALSVDEVA 560 AALRATLEQA 570 AASARPTFPG 580 LRVPVTPGEL 590 LTAEIIDQDV 600 FEQLERGQAT 610 AQDVGSLDSV 620 QRYLQGTGCI 630 AGVLPPGSQE 640 PLGIREACGK 650 GLLRPGTALI 660 LLEAQAATGF 670 IIDPKENRRY 680 SVEEALRAGV 690 IGPEMFEKLL 700 SAERAVTGYT 710 DPYTGEQISL 720 FQAMKKDLIV 730 REHGLRLLEA 740 QIATGGVIDP 750 VHSHRVPVDV 760 AYQRGYFDEE 770 LSRVLEDPSD 780 DTKGFFDPNT 790 HENLTYMQLL 800 ERCVRDPDTG 810 LFLLPLTSSR 820 PQLVDGATRQ 830 AFQSLLILVK 840 FGRFRGQKVS 850 AWDLLNSEYF 860 SETARRRLLQ 870 RYRLRQVSLE 880 EISELLEREM 890 ERWADITLPA 900 LRGRVTAYQL 910 LEARIIDQEL 920 LARVLAGAVS 930 PEALLRMDQV 940 RRYLRGSGAV 950 GGVLLQPSNR 960 RLSLYQAMKQ 970 KLLGPGVALA 980 LLEAQAATGA 990 ITDACSLEAV 1000 SVDEAVRREL 1010 VGPELCGRLR 1020 QAEDAVTGLQ 1030 DPFSGKRVSL 1040 FQAMRKGLVP 1050 VEQAVRLLDA 1060 QVATGGVIDP 1070 TGHHHLPMPV 1080 AIQRGCVDQD 1090 MELALSSCEP 1100 FPTPDGRGHT 1110 SYAQLLEQCV 1120 RDEASGLHLL 1130 PLSESAPAVP 1140 TDEQLQETLQ 1150 ATRGEDGTSV 1160 WELLGSCHFT 1170 EEQRRAFLED 1180 FRVGKSTAQQ 1190 LLEALQRGLR 1200 EAELLARARV 1210 ALPGPRGEVP 1220 AVWLLDAGVI 1230 TQETLAALVQ 1240 GVWSPTEVAR 1250 QPGVQACLWG 1260 MGCVAGVLLP 1270 SGAKASIAQA 1280 VRDGLLPVGL 1290 GQRLLEAQVA 1300 SGSLIDPLTS 1310 QRLSVEGAVK 1320 AGLVAGALSE 1330 RLRHVERVVA 1340 GYTDPYSGGS 1350 LSLWQAVEKG 1360 LVPQSEGFPL 1370 LQAQLATGGA 1380 MDPDHGVHLP 1390 QAAACRLGLL 1400 DERTSTKLTS 1410 TEDDVKFFFD 1420 PSARDRVTYE 1430 QLKERCVLDA 1440 DTGLWLLPVP 1450 QDVALAVDEH 1460 TAVALRAMKV 1470 PVGAGRFRGL 1480 SVSLWDLLHS 1490 EYVGAQRRQE 1500 LAVLCQSGRA 1510 TALRQVVREV 1520 TSLVEASEAQ 1530 PSKATFRGLR 1540 KQVSASDLFR 1550 SQLIDKKTLD 1560 ELNQGKKSVR 1570 EVTAMDGVRR 1580 FLEGGNFIAG 1590 VLVQSTKEKM 1600 SISEALRRHI 1610 LRPGTALVLL 1620 EAQAATGFLI 1630 DPVENRKLTV 1640 QEAFEAGMFG 1650 RETYQKLLSA 1660 ERAVTGYTDP 1670 YTGEQISLFQ 1680 AMKKDLIVRE 1690 HGIRLLEAQI 1700 ATGGIIDPVR 1710 SHRVPVAVAY 1720 QRGYFDEEMS 1730 RVLEDPSDDT 1740 KGFFDPNTHE 1750 NLTYMQLLER 1760 CVRDPDTGLF 1770 LLQVVKKGET 1780 YVYIDEATRQ 1790 ALRNRTARMP 1800 VGSFADQTVS 1810 LWDLLCSQYF 1820 TEERKRALVQ 1830 EYRAQKLSLE 1840 ALLESITTTV 1850 QDTEAKNQVI 1860 KVAGIGGEVT 1870 AAELFNSGVV 1880 DKETLDQVAE 1890 AEGGGPGLGS 1900 LPHVRAYLEG 1910 SGCIAGVTTP 1920 TAHEVMGIYD 1930 ASRKGLLPPE 1940 VAAQLLEAQA 1950 ATGFMLDPCR 1960 QQKFSVDEAV 1970 AAGLVGEELQ 1980 ERLLSAETAA 1990 KGYPDPETGH 2000 TISLFQAMKR 2010 KLVKRDWALR 2020 LLEVQVATGG 2030 LVDSEHHHRL 2040 PLDVAYRRGY 2050 LHPDTYPLIA 2060 DQKCMNKRFV 2070 DPSRREKVTY 2080 QELQERSHRQ 2090 ESTGWALLPL 2100 LSNQEDDAVI 2110 DEATRRALAA 2120 EQVEVTVGRF 2130 KGQRPTVWDL 2140 LNSEYVTEEK 2150 KLELVAKYKR 2160 DTKHELEKVV 2170 KVILQIIEEN 2180 EKKKQQLWFR 2190 GIRTQVTAAD 2200 LFHAAVISRE 2210 MLADLEGGRA 2220 SVDEVQQQEP 2230 VRRYLEGTSC 2240 IAGVLVPAKD 2250 EPGRQEKMSI 2260 YQAMWKGVLR 2270 PGTALVLLEA 2280 QAATGFVIDP 2290 VRNQKLSVEE 2300 AVAAGVVGGE 2310 LREKLLSAER 2320 AVTGYTDPYT 2330 GEQISLFQAM 2340 KKDLIVREHG 2350 IRLLEAQIAT 2360 GGVIDPVRSH 2370 RVPVDVAYQR 2380 GYFDEEMSRV 2390 LEDPSDDTKG 2400 FFDPNTHENL 2410 TYMQLLRRCV 2420 RDPDTGLFML 2430 QLAGPGSAVH 2440 QLGEELRAAL 2450 RDARVTLGSG 2460 LLRGQSASVW 2470 ELLFYREAMW 2480 KGVLRPGTAL 2490 VLLEAQAATG 2500 FVIDPVRNQK 2510 LSVEEAVAAG 2520 VVGGELREKL 2530 LSAERAVTGY 2540 TDPYTGEQIS 2550 LFQAMKKDLI 2560 VREHGIRLLE 2570 AQIATGGVID 2580 PVRSHRVPVD 2590 VAYQRGYFDE 2600 EMSRVLEDPS 2610 DDTKGFFDPN 2620 THENLTYMQL 2630 LRRCVRDPDT 2640 GLFMLQLAGP 2650 GSAVHQLGEE 2660 LRAALRDARV 2670 TLGSGLLRGQ 2680 SASVWELLFY 2690 REVSESQRQD 2700 LLGRYRAGSL 2710 TAQEVGAALA 2720 SLLARAGAEA 2730 EAGAGAGAGA 2740 PLPGVPDPGA 2750 ALRAATMEVR 2760 VGRLRGPAVP 2770 VWDVLASSYV 2780 SGATREQLLA 2790 QFGSGALGLP 2800 ALTRRLTTIV 2810 EEAEEARGTQ 2820 GPPAGHGHGD 2830 AGPSPGQGQG 2840 QAEAEAARAL 2850 QEQTLRAATM 2860 EVRAGRFRGQ 2870 PVSVWDVLSS 2880 SYLGQARRDE 2890 LLAQHAAGAL 2900 ALPALVATLT 2910 QVIEETEERL 2920 SKVSFRGLRR 2930 QVSASELHTS 2940 GILGPETLRD 2950 LAQGTRTLQE 2960 VTEMDAVKRY 2970 LEGTSCIAGV 2980 LVPAKDEPGR 2990 QEKMSIYQAM 3000 WKGVLRPGTA 3010 LVLLEAQAAT 3020 GFVIDPVRNQ 3030 KLSVEEAVAA 3040 GVVGGELREK 3050 LLSAERAVTG 3060 YTDPYTGEQI 3070 SLFQAMKKDL 3080 IVREHGIRLL 3090 EAQIATGGVI 3100 DPVRSHRVPV 3110 DVAYQRGYFD 3120 EEMSRVLEDP 3130 SDDTKGFFDP 3140 NTHENLTYMQ 3150 LLRRCVRDPD 3160 TGLFMLQLAG 3170 PGSAVHQLGE 3180 ELRAALRDAR 3190 VTLGSGLLRG 3200 QSASVWELLF 3210 YREVSESQRQ 3220 DLLGRYRAGS 3230 LTAQEVGAAL 3240 ASLLARAGAE 3250 AEAGAGAGAG 3260 APLPGVPDPG 3270 AALRAATMEV 3280 RVGRLRGPAV 3290 PVWDVLASSY 3300 VSGATREQLL 3310 AQFGSGALGL 3320 PALTRRLTTI 3330 VEEAEEARGT 3340 QGPPAGHGHG 3350 DAGPSPGQGQ 3360 GQAEAEAARA 3370 LQEQTLRAAT 3380 MEVRAGRFRG 3390 QPVSVWDVLS 3400 SSYLGQARRD 3410 ELLAQHAAGA 3420 LALPALVATL 3430 TQVIEETEER 3440 LSKVSFRGLR 3450 RQVSASELHT 3460 SGILGPETLR 3470 DLAQGTRTLQ 3480 EVTEMDAVKR 3490 YLEGTSCIAG 3500 VLVPAKDEPG 3510 RQEKMSIYQA 3520 MWKGVLRPGT 3530 ALVLLEAQAA 3540 TGFVIDPVRN 3550 QKLSVEEAVA 3560 AGVVGGELRE 3570 KLLSAERAVT 3580 GYTDPYTGEQ 3590 ISLFQAMKKD 3600 LIVREHGIRL 3610 LEAQIATGGV 3620 IDPVRSHRVP 3630 VDVAYQRGYF 3640 DEEMSRGQGQ 3650 AEAEAARALQ 3660 EQTLRAATME 3670 VRAGRFRGQP 3680 VSVWDVLSSS 3690 YLGQARRDEL 3700 LAQHAAGALA 3710 LPALVATLTQ 3720 VIEETEERLS 3730 KVSFRGLRRQ 3740 VSASELHTSG 3750 ILGPETLRDL 3760 AQGTRTLQEV 3770 TEMDAVKRYL 3780 EGTSCIAGVL 3790 VPAKDEPGRQ 3800 EKMSIYQAMW 3810 KGVLRPGTAL 3820 VLLEAQAATG 3830 FVIDPVRNQK 3840 LSVEEAVAAG 3850 VVGGELREKL 3860 LSAERAVTGY 3870 TDPYTGEQIS 3880 LFQAMKKDLI 3890 VREHGIRLLE 3900 AQIATGGVID 3910 PVRSHRVPVD 3920 VAYQRGYFDE 3930 EMSRVLEDPS 3940 DDTKGFFDPN 3950 THENLTYMQL 3960 LQRATRDPDT 3970 GLLFLSLSGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0030054 cell junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030056 hemidesmosome
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0016020 membrane
Cellular Component GO:0097356 perinucleolar compartment
Molecular Function GO:1990254 keratin filament binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0045110 intermediate filament bundle assembly
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0042060 wound healing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.