Overview
| Uniprot ID | A0A8W4FFH6 |
| Protein Name | Epiplakin |
| Gene Name | EPPK1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 118 |
VGLELKEKLLAAERA |
| 1397 |
LDERTSTKLTSTEDD |
| 1646 |
FGRETYQKLLSAERA |
| 26 |
AAVPKSVKATLGADA |
| 390 |
PLFQAMKKELVDRPL |
Function
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization
Protein Sequence
10
MNGHASSLDV
20
LVTNGTELAA
30
VPKSVKATLG
40
ADAPSEPQAQ
50
APASAQARGI
60
AGVYVEASGQ
70
AQSLYAAMKQ
80
GLLPFGLGLA
90
LLEAQAATGG
100
LVDPAQGRPL
110
LVSEALQQGL
120
VGLELKEKLL
130
AAERAVTGYP
140
DPYGGERLAL
150
FQAIGKEVVG
160
RALGWSWLEA
170
QLATGGLVDP
180
TRGGRVAPEL
190
ACQQGLLDQE
200
TWRGLTELGP
210
GSSAPGFLDP
220
NTLEELPYRE
230
LLGRCVRAPG
240
SGLALLPLKT
250
TFRTLSGAVS
260
LAELLEVGIL
270
DPGTARGLRE
280
GGLAVQDVSA
290
RAEVQRYLQG
300
TGGMAGVVLL
310
PAGHKKSFFQ
320
AAAEHLLPAG
330
ATLPLLEAQA
340
ATCTLVDPAT
350
GRQLCVDEAV
360
RAGLVGPELH
370
RQLLAAEQAV
380
MGYPDPFSGT
390
RIPLFQAMKK
400
ELVDRPLALR
410
LLDAQLATGG
420
LVCPTRRLRL
430
PLEAALRFGC
440
LDEETQQHLS
450
QAAGFSDPGT
460
QESLSYGQLL
470
ARCVTDPETG
480
LAFLPVSAGS
490
LGEEPRGPPF
500
IEHSTRQALR
510
AATATISVGK
520
FQGRPVSLWE
530
LLFSEAVPVE
540
QRITLTQQHK
550
DGALSVDEVA
560
AALRATLEQA
570
AASARPTFPG
580
LRVPVTPGEL
590
LTAEIIDQDV
600
FEQLERGQAT
610
AQDVGSLDSV
620
QRYLQGTGCI
630
AGVLPPGSQE
640
PLGIREACGK
650
GLLRPGTALI
660
LLEAQAATGF
670
IIDPKENRRY
680
SVEEALRAGV
690
IGPEMFEKLL
700
SAERAVTGYT
710
DPYTGEQISL
720
FQAMKKDLIV
730
REHGLRLLEA
740
QIATGGVIDP
750
VHSHRVPVDV
760
AYQRGYFDEE
770
LSRVLEDPSD
780
DTKGFFDPNT
790
HENLTYMQLL
800
ERCVRDPDTG
810
LFLLPLTSSR
820
PQLVDGATRQ
830
AFQSLLILVK
840
FGRFRGQKVS
850
AWDLLNSEYF
860
SETARRRLLQ
870
RYRLRQVSLE
880
EISELLEREM
890
ERWADITLPA
900
LRGRVTAYQL
910
LEARIIDQEL
920
LARVLAGAVS
930
PEALLRMDQV
940
RRYLRGSGAV
950
GGVLLQPSNR
960
RLSLYQAMKQ
970
KLLGPGVALA
980
LLEAQAATGA
990
ITDACSLEAV
1000
SVDEAVRREL
1010
VGPELCGRLR
1020
QAEDAVTGLQ
1030
DPFSGKRVSL
1040
FQAMRKGLVP
1050
VEQAVRLLDA
1060
QVATGGVIDP
1070
TGHHHLPMPV
1080
AIQRGCVDQD
1090
MELALSSCEP
1100
FPTPDGRGHT
1110
SYAQLLEQCV
1120
RDEASGLHLL
1130
PLSESAPAVP
1140
TDEQLQETLQ
1150
ATRGEDGTSV
1160
WELLGSCHFT
1170
EEQRRAFLED
1180
FRVGKSTAQQ
1190
LLEALQRGLR
1200
EAELLARARV
1210
ALPGPRGEVP
1220
AVWLLDAGVI
1230
TQETLAALVQ
1240
GVWSPTEVAR
1250
QPGVQACLWG
1260
MGCVAGVLLP
1270
SGAKASIAQA
1280
VRDGLLPVGL
1290
GQRLLEAQVA
1300
SGSLIDPLTS
1310
QRLSVEGAVK
1320
AGLVAGALSE
1330
RLRHVERVVA
1340
GYTDPYSGGS
1350
LSLWQAVEKG
1360
LVPQSEGFPL
1370
LQAQLATGGA
1380
MDPDHGVHLP
1390
QAAACRLGLL
1400
DERTSTKLTS
1410
TEDDVKFFFD
1420
PSARDRVTYE
1430
QLKERCVLDA
1440
DTGLWLLPVP
1450
QDVALAVDEH
1460
TAVALRAMKV
1470
PVGAGRFRGL
1480
SVSLWDLLHS
1490
EYVGAQRRQE
1500
LAVLCQSGRA
1510
TALRQVVREV
1520
TSLVEASEAQ
1530
PSKATFRGLR
1540
KQVSASDLFR
1550
SQLIDKKTLD
1560
ELNQGKKSVR
1570
EVTAMDGVRR
1580
FLEGGNFIAG
1590
VLVQSTKEKM
1600
SISEALRRHI
1610
LRPGTALVLL
1620
EAQAATGFLI
1630
DPVENRKLTV
1640
QEAFEAGMFG
1650
RETYQKLLSA
1660
ERAVTGYTDP
1670
YTGEQISLFQ
1680
AMKKDLIVRE
1690
HGIRLLEAQI
1700
ATGGIIDPVR
1710
SHRVPVAVAY
1720
QRGYFDEEMS
1730
RVLEDPSDDT
1740
KGFFDPNTHE
1750
NLTYMQLLER
1760
CVRDPDTGLF
1770
LLQVVKKGET
1780
YVYIDEATRQ
1790
ALRNRTARMP
1800
VGSFADQTVS
1810
LWDLLCSQYF
1820
TEERKRALVQ
1830
EYRAQKLSLE
1840
ALLESITTTV
1850
QDTEAKNQVI
1860
KVAGIGGEVT
1870
AAELFNSGVV
1880
DKETLDQVAE
1890
AEGGGPGLGS
1900
LPHVRAYLEG
1910
SGCIAGVTTP
1920
TAHEVMGIYD
1930
ASRKGLLPPE
1940
VAAQLLEAQA
1950
ATGFMLDPCR
1960
QQKFSVDEAV
1970
AAGLVGEELQ
1980
ERLLSAETAA
1990
KGYPDPETGH
2000
TISLFQAMKR
2010
KLVKRDWALR
2020
LLEVQVATGG
2030
LVDSEHHHRL
2040
PLDVAYRRGY
2050
LHPDTYPLIA
2060
DQKCMNKRFV
2070
DPSRREKVTY
2080
QELQERSHRQ
2090
ESTGWALLPL
2100
LSNQEDDAVI
2110
DEATRRALAA
2120
EQVEVTVGRF
2130
KGQRPTVWDL
2140
LNSEYVTEEK
2150
KLELVAKYKR
2160
DTKHELEKVV
2170
KVILQIIEEN
2180
EKKKQQLWFR
2190
GIRTQVTAAD
2200
LFHAAVISRE
2210
MLADLEGGRA
2220
SVDEVQQQEP
2230
VRRYLEGTSC
2240
IAGVLVPAKD
2250
EPGRQEKMSI
2260
YQAMWKGVLR
2270
PGTALVLLEA
2280
QAATGFVIDP
2290
VRNQKLSVEE
2300
AVAAGVVGGE
2310
LREKLLSAER
2320
AVTGYTDPYT
2330
GEQISLFQAM
2340
KKDLIVREHG
2350
IRLLEAQIAT
2360
GGVIDPVRSH
2370
RVPVDVAYQR
2380
GYFDEEMSRV
2390
LEDPSDDTKG
2400
FFDPNTHENL
2410
TYMQLLRRCV
2420
RDPDTGLFML
2430
QLAGPGSAVH
2440
QLGEELRAAL
2450
RDARVTLGSG
2460
LLRGQSASVW
2470
ELLFYREAMW
2480
KGVLRPGTAL
2490
VLLEAQAATG
2500
FVIDPVRNQK
2510
LSVEEAVAAG
2520
VVGGELREKL
2530
LSAERAVTGY
2540
TDPYTGEQIS
2550
LFQAMKKDLI
2560
VREHGIRLLE
2570
AQIATGGVID
2580
PVRSHRVPVD
2590
VAYQRGYFDE
2600
EMSRVLEDPS
2610
DDTKGFFDPN
2620
THENLTYMQL
2630
LRRCVRDPDT
2640
GLFMLQLAGP
2650
GSAVHQLGEE
2660
LRAALRDARV
2670
TLGSGLLRGQ
2680
SASVWELLFY
2690
REVSESQRQD
2700
LLGRYRAGSL
2710
TAQEVGAALA
2720
SLLARAGAEA
2730
EAGAGAGAGA
2740
PLPGVPDPGA
2750
ALRAATMEVR
2760
VGRLRGPAVP
2770
VWDVLASSYV
2780
SGATREQLLA
2790
QFGSGALGLP
2800
ALTRRLTTIV
2810
EEAEEARGTQ
2820
GPPAGHGHGD
2830
AGPSPGQGQG
2840
QAEAEAARAL
2850
QEQTLRAATM
2860
EVRAGRFRGQ
2870
PVSVWDVLSS
2880
SYLGQARRDE
2890
LLAQHAAGAL
2900
ALPALVATLT
2910
QVIEETEERL
2920
SKVSFRGLRR
2930
QVSASELHTS
2940
GILGPETLRD
2950
LAQGTRTLQE
2960
VTEMDAVKRY
2970
LEGTSCIAGV
2980
LVPAKDEPGR
2990
QEKMSIYQAM
3000
WKGVLRPGTA
3010
LVLLEAQAAT
3020
GFVIDPVRNQ
3030
KLSVEEAVAA
3040
GVVGGELREK
3050
LLSAERAVTG
3060
YTDPYTGEQI
3070
SLFQAMKKDL
3080
IVREHGIRLL
3090
EAQIATGGVI
3100
DPVRSHRVPV
3110
DVAYQRGYFD
3120
EEMSRVLEDP
3130
SDDTKGFFDP
3140
NTHENLTYMQ
3150
LLRRCVRDPD
3160
TGLFMLQLAG
3170
PGSAVHQLGE
3180
ELRAALRDAR
3190
VTLGSGLLRG
3200
QSASVWELLF
3210
YREVSESQRQ
3220
DLLGRYRAGS
3230
LTAQEVGAAL
3240
ASLLARAGAE
3250
AEAGAGAGAG
3260
APLPGVPDPG
3270
AALRAATMEV
3280
RVGRLRGPAV
3290
PVWDVLASSY
3300
VSGATREQLL
3310
AQFGSGALGL
3320
PALTRRLTTI
3330
VEEAEEARGT
3340
QGPPAGHGHG
3350
DAGPSPGQGQ
3360
GQAEAEAARA
3370
LQEQTLRAAT
3380
MEVRAGRFRG
3390
QPVSVWDVLS
3400
SSYLGQARRD
3410
ELLAQHAAGA
3420
LALPALVATL
3430
TQVIEETEER
3440
LSKVSFRGLR
3450
RQVSASELHT
3460
SGILGPETLR
3470
DLAQGTRTLQ
3480
EVTEMDAVKR
3490
YLEGTSCIAG
3500
VLVPAKDEPG
3510
RQEKMSIYQA
3520
MWKGVLRPGT
3530
ALVLLEAQAA
3540
TGFVIDPVRN
3550
QKLSVEEAVA
3560
AGVVGGELRE
3570
KLLSAERAVT
3580
GYTDPYTGEQ
3590
ISLFQAMKKD
3600
LIVREHGIRL
3610
LEAQIATGGV
3620
IDPVRSHRVP
3630
VDVAYQRGYF
3640
DEEMSRGQGQ
3650
AEAEAARALQ
3660
EQTLRAATME
3670
VRAGRFRGQP
3680
VSVWDVLSSS
3690
YLGQARRDEL
3700
LAQHAAGALA
3710
LPALVATLTQ
3720
VIEETEERLS
3730
KVSFRGLRRQ
3740
VSASELHTSG
3750
ILGPETLRDL
3760
AQGTRTLQEV
3770
TEMDAVKRYL
3780
EGTSCIAGVL
3790
VPAKDEPGRQ
3800
EKMSIYQAMW
3810
KGVLRPGTAL
3820
VLLEAQAATG
3830
FVIDPVRNQK
3840
LSVEEAVAAG
3850
VVGGELREKL
3860
LSAERAVTGY
3870
TDPYTGEQIS
3880
LFQAMKKDLI
3890
VREHGIRLLE
3900
AQIATGGVID
3910
PVRSHRVPVD
3920
VAYQRGYFDE
3930
EMSRVLEDPS
3940
DDTKGFFDPN
3950
THENLTYMQL
3960
LQRATRDPDT
3970
GLLFLSLSGK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016327 |
apicolateral plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030056 |
hemidesmosome |
| Cellular Component |
GO:0045095 |
keratin filament |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0097356 |
perinucleolar compartment |
| Molecular Function |
GO:1990254 |
keratin filament binding |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0045110 |
intermediate filament bundle assembly |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0050680 |
negative regulation of epithelial cell proliferation |
| Biological Process |
GO:0061045 |
negative regulation of wound healing |
| Biological Process |
GO:0042060 |
wound healing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.