Search Results
Overview
| Uniprot ID | A0A8W4FFH8 |
|---|---|
| Protein Name | Cathepsin D |
| Gene Name | CTSD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 266 | TLGGKKYKLSSENYT |
| 42 | IACWIHHKYNSGKSS |
| 47 | HHKYNSGKSSTYVKN |
Function
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation
Protein Sequence
10
GPIGIGTPPQ
20
CFTVVFDTGS
30
SNLWVPSIHC
40
KLLDIACWIH
50
HKYNSGKSST
60
YVKNGTTFAI
70
HYGSGSLSGY
80
LSQDTVSVPC
90
NSASSGVGGI
100
KVERQTFGEA
110
TKQPGLTFIA
120
AKFDGILGMA
130
YPRISVNNVV
140
PVFDNLMQQK
150
LVDKNIFSFY
160
LNRDPGAQPG
170
GELMLGGIDS
180
KYYKGSLDYH
190
NVTRKAYWQI
200
HMDQVAVGSS
210
LTLCKGGCEA
220
IVDTGTSLIV
230
GPVEEVRELQ
240
KAIGAVPLIQ
250
GEYMIPCEKV
260
PSLPDVTVTL
270
GGKKYKLSSE
280
NYTLKVSQAG
290
QTICLSGFMG
300
MDIPPPGGPL
310
WILGDVFIGR
320
YYTVFDRDLN
330
RVGLAEAATL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Molecular Function | GO:0004190 | aspartic-type endopeptidase activity |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.