Search Results

Overview

Uniprot IDA0A8W4FFJ0
Protein NameNeurofibromin
Gene NameNF1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
476 KEKVTSLKFKEKPTD

Function

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity

Protein Sequence

10 MAAHRPVEWV 20 QAVVSRFDEQ 30 LPIKTGQQNT 40 HTKVSTEHNK 50 ECLINISKYK 60 FSLVISGLTT 70 ILKNVNNMRI 80 FGEAAEKNLY 90 LSQLIILDTL 100 EKCLAGQPKD 110 TMRLDETMLV 120 KQLLPEICHF 130 LHTCREGNQH 140 AAELRNSASG 150 VLFSLSCNNF 160 NAVFSRISTR 170 LQELTVCSED 180 NVDVHDIELL 190 QYINVDCAKL 200 KRLLKETAFK 210 FKALKKVAQL 220 AVINSLEKAF 230 WNWVENYPDE 240 FTKLYQVPQT 250 DMAECAEKLF 260 DLVDGFAEST 270 KRKAAVWPLQ 280 IILLILCPEI 290 IQDISKDVVD 300 ENNMNKKLFL 310 DSLRKALAGH 320 GGSRQLTESA 330 AIACVKLCKA 340 STYINWEDNS 350 VIFLLVQSMV 360 VDLKNLLFNP 370 SKPFSRGSQP 380 ADVDLMIDCL 390 VSCFRISPHN 400 NQHFKICLAQ 410 NSPSTFHYVL 420 VNSLHRIITN 430 SALDWWPKID 440 AVYCHSVELR 450 NMFGETLHKA 460 VQGCGAHPAI 470 RMAPSLTFKE 480 KVTSLKFKEK 490 PTDLETRSYK 500 YLLLSMVKLI 510 HADPKLLLCN 520 PRKQGPETQG 530 STAELITGLV 540 QLVPQSHMPE 550 IAQEAMEALL 560 VLHQLDSIDL 570 WNPDAPVETF 580 WEISSQMLFY 590 ICKKLTSHQM 600 LSSTEILKWL 610 REILICRNKF 620 LLKNKQADRS 630 SCHFLFLYGV 640 GCDIPSSGNT 650 SQIPMDHEEL 660 LRTCTPGTSL 670 RRGKGNSSMD 680 SAAGYSGTPP 690 ICRQAQTKLE 700 VALYMFLWSP 710 DTEAVLVAMS 720 CFRHLCEEAD 730 IRCGVDEVSV 740 HNFLPNYNTF 750 MEFASVSNMM 760 STGRTALQKR 770 VMALLRRIEH 780 PAGNTEAWED 790 THAKWEQATK 800 LILNYPKAKM 810 EDGQAAESLH 820 KTIVKRRMSH 830 VSGGGSIDLS 840 DTDSLQEWIN 850 MTGFLCALGG 860 VCLQQRSNSG 870 LATYSPPMGP 880 VSERKGSMIS 890 VMSSEGNADT 900 PVSKFMDRLL 910 SLMVCNHEKV 920 GLQIRTNVKD 930 LVGLELSPAL 940 YPMLFNKLKN 950 TISKFFDSQG 960 QVLLTDTNTQ 970 FVEQTIAIMK 980 NLLDNHTEGS 990 SEHLGQASIE 1000 TMMLNLVRYV 1010 RVLGNMVHAI 1020 QIKTKLCQLV 1030 EVMMARRDDL 1040 SFCQEMKFRN 1050 KMVEYLTDWV 1060 MGTSNQAADD 1070 DVKCLTRDLD 1080 QASMEAVVSL 1090 LAGLPLQPEE 1100 GDGVELMEAK 1110 SQLFLKYFTL 1120 FMNLLNDCSE 1130 VEDENAQTGG 1140 RKRGMSRRLA 1150 SLRHCTVLAM 1160 SNLLNANVDS 1170 GLMHSIGLGY 1180 HKDLQTRATF 1190 MEVLTKILQQ 1200 GTEFDTLAET 1210 VLADRFERLV 1220 ELVTMMGDQG 1230 ELPIAMALAN 1240 VVPCSQWDEL 1250 ARVLVTLFDS 1260 RHLLYQLLWN 1270 MFSKEVELAD 1280 SMQTLFRGNS 1290 LASKIMTFCF 1300 KVYGATYLQK 1310 LLDPLLRIVI 1320 TSSDWQHVSF 1330 EVDPTRLEQS 1340 ESLEENQRNL 1350 LQMTEKFFHA 1360 IISSSSEFPP 1370 QLRSVCHCLY 1380 QATCHSLLNK 1390 ATVKEKKENK 1400 KSVVSQRFPQ 1410 NSIGAVGSAM 1420 FLRFINPAIV 1430 SPYEAGILDK 1440 KPPPRIERGL 1450 KLMSKILQSI 1460 ANHVLFTKEE 1470 HMRPFNDFVK 1480 SNFDAARRFF 1490 LDIASDCPTS 1500 DAVNHSLSFI 1510 SDGNVLALHR 1520 LLWNNQEKIG 1530 QYLSSNRDHK 1540 AVGRRPFDKM 1550 ATLLAYLGPP 1560 EHKPVADTHW 1570 SSLNLTSSKF 1580 EEFMTRHQVH 1590 EKEEFKALKT 1600 LSIFYQAGTS 1610 KAGNPIFYYV 1620 ARRFKTGQIN 1630 GDLLIYHVLL 1640 TLKPYYAKPY 1650 EIVVDLTHTG 1660 PSNRFKTDFL 1670 SKWFVVFPGF 1680 AYDNVSAVYI 1690 YNCNSWVREY 1700 TKYHERLLTG 1710 LKGSKRLIFI 1720 DCPGKLAEHI 1730 EHEQQKLPAA 1740 TLALEEDLKV 1750 FHNALKLAHK 1760 DTKVSIKVGS 1770 TAVQVTSAER 1780 TKVLGQSVFL 1790 NDIYYASEIE 1800 EICLVDENQF 1810 TLTIANQGTP 1820 LTFMHQECDA 1830 IVQSIIHIRT 1840 RWELSQPDSI 1850 PQHTKIRPKD 1860 VPGTLLNIAL 1870 LNLGSSDPSL 1880 RSAAYNLLCA 1890 LTCTFNLKIE 1900 GQLLETSGLC 1910 IPANNTLFIV 1920 SISKTLAANE 1930 PHLTLEFLEE 1940 CISGFSKSSI 1950 ELKHLCLEYM 1960 TPWLSNLVRF 1970 CKHNDDAKRQ 1980 RVTAILDKLI 1990 TMTINEKQMY 2000 PSIQAKIWGS 2010 LGQITDLLDV 2020 VLDSFIKTSA 2030 TGGLGSIKAE 2040 VMADTAVALA 2050 SGNVKLVSSK 2060 VIGRMCKIID 2070 KTCLSPTPTL 2080 EQHLMWDDIA 2090 ILARYMLMLS 2100 FNNSLDVAAH 2110 LPYLFHVVTF 2120 LVATGPLSLR 2130 ASTHGLVINI 2140 IHSLCTCSQL 2150 HFSEETKQVL 2160 RLSLTEFSLP 2170 KFYLLFGISK 2180 VKSAAVIAFR 2190 SSYRDRSFSP 2200 GSYERETFAL 2210 TSLETVTEAL 2220 LEIMEACMRD 2230 IPTCKWLDQW 2240 TELAQRFAFQ 2250 YNPSLQPRAL 2260 VVFGCISKRV 2270 SHGQIKQIIR 2280 ILSKALESCL 2290 KGPETYNSQV 2300 LIEATVIALT 2310 KLQPLLNKDS 2320 PLHKALFWVA 2330 VAVLQLDEVN 2340 LYSAGTALLE 2350 QNLHTLDSLR 2360 IFNDKSPEEV 2370 FMAIRNPLEW 2380 HCKQMDHFVG 2390 LNFNSNFNFA 2400 LVGHLLKGYR 2410 HPSPAIVART 2420 VRILHTLLTL 2430 VNKHRNCDKF 2440 EVNTQSVAYL 2450 AALLTVSEEV 2460 RSRCSLKHRK 2470 SLLLTDISME 2480 NVPMDTYPIH 2490 HGDPSYRALK 2500 ENQPWSSPKG 2510 SEGYLAASYP 2520 TAGQTSPRAR 2530 KSMSLDMGQP 2540 SQANTKKLLG 2550 TRKSFDHLIS 2560 DTKAPKRQEM 2570 ESGITTPPKM 2580 RRVAETDYEM 2590 ETQRISSSQH 2600 PHLRKVSVSE 2610 SNVLLDEEVL 2620 TDPKIQALLL 2630 TVLATLVKYT 2640 TDEFDQRILY 2650 EYLAEASVVF 2660 PKVFPVVHNL 2670 LDSKINTLLS 2680 LCQDPNLLNP 2690 IHGIVQSVVY 2700 HEESPPQYQT 2710 SYLQSFGFNG 2720 LWRFAGPFSK 2730 QTQIPDYAEL 2740 IVKFLDALID 2750 TYLPGIDEET 2760 SEESLLTPTS 2770 PYPPAVQSQL 2780 SITANLNLSN 2790 SMTSLATSQH 2800 SPGIDKENVE 2810 LSPTTGHCNS 2820 GRTRHGSASQ 2830 VQKQRSAGSF KRTSIKKIV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030424 axon
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0031210 phosphatidylcholine binding
Molecular Function GO:0008429 phosphatidylethanolamine binding
Biological Process GO:0050890 cognition
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0043535 regulation of blood vessel endothelial cell migration
Biological Process GO:1902531 regulation of intracellular signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.