Search Results
Overview
| Uniprot ID | A0A8W4FFR4 |
|---|---|
| Protein Name | Histidine--tRNA ligase, cytoplasmic |
| Gene Name | HARS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | LKETLTGKYGEDSKL |
| 154 | IKRYHIAKVYRRDNP |
| 382 | VLVASAQKKLLEERL |
| 42 | VAKLLKLKAQLGPDE |
Function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance
Protein Sequence
10
MAGRETLEEL
20
VRLQGERVRG
30
LKQQKASTEQ
40
IEEEVAKLLK
50
LKAQLGPDEG
60
KHKFVLKTPK
70
GTRDYSPRQM
80
AVREKVFDVI
90
IGCFKRHGAE
100
VIDTPVFELK
110
ETLTGKYGED
120
SKLIYDLKDQ
130
GGELLSLRYD
140
LTVPFARYLA
150
MNKLTNIKRY
160
HIAKVYRRDN
170
PAMTRGRYRE
180
FYQCVNDRRI
190
LDGLFAICGV
200
PDTKFRTICS
210
SVDKLDKMSW
220
EEVKNEMVGE
230
KGLAPEVADR
240
IGDYVQQHGG
250
VSLVEQLLQD
260
PKLSQNKQAL
270
EGLGDLKLLF
280
EYLTLFGVAD
290
KISFDLSLAR
300
GLDYYTGVIY
310
EAVLLQPPAQ
320
AGEEPLGVGS
330
VAAGGRYDGL
340
VGMFDPKGRK
350
VPCVGLSIGV
360
ERIFSIVEQR
370
LEALEEKVRT
380
TETQVLVASA
390
QKKLLEERLK
400
LVSELWDAGI
410
KAELLYKKNP
420
KLLNQLQYCE
430
EAGIPLVAII
440
GEQELKDGVV
450
KLRSVTSREE
460
VDVRREDLVE
470
EIKRRTSQPS
CTC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004821 | histidine-tRNA ligase activity |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.