Search Results
Overview
| Uniprot ID | A0A8W4FFZ6 |
|---|---|
| Protein Name | Prothrombin |
| Gene Name | F2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 593 | EGCDRDGKYGFYTHV |
Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells
Protein Sequence
10
MAHVGGLWLP
20
GCLALAVLVS
30
LVHSQHVFMA
40
PQQALSLLQR
50
ARRANSGFFE
60
EMRKGNLERE
70
CVEEQCSREE
80
AYEALESPSE
90
TVTCESVRKS
100
REKLVECLEG
110
NCAEGLGMNY
120
RGNISVTRSG
130
IECQLWRSRY
140
PHKPEVNSTM
150
YPGADLRENF
160
CRNPDGSITG
170
PWCYTTSPTV
180
RREACSIPVC
190
GQGRVTAELI
200
PRSGGSTVNV
210
SPPLETCVPE
220
RGRQYQGRLA
230
VTSHGSPCLA
240
WGSSQAKALS
250
KDQDFNPAVP
260
LVENFCRNPD
270
GDQEGAWCYV
280
AGQPGDFEYC
290
DLDYCEEPVD
300
EEVGDALGEN
310
ADAAIEGRTT
320
ADDFQPFFNE
330
KTFGAGEADC
340
GLRPLFEKSS
350
LEDKTEKELF
360
ESYIEGRIVE
370
GSDAEIGLAP
380
WQVMIFRKSP
390
QELLCGASLI
400
SDRWVLTAAH
410
CLLYPPWDKN
420
FTENDLLVRI
430
GKHSRTRYER
440
NIEKISMLEK
450
IYIHPRYNWR
460
ENLDRDIALL
470
KLRKPITFSD
480
YIHPVCLPDK
490
ETATKLLRAG
500
YKGRVTGWGN
510
LKETWTTSAS
520
EVQPSVLQVV
530
NLPIVERLVC
540
KASTRIRITD
550
NMFCAGYKPD
560
EGKRGDACEG
570
DSGGPFVMKS
580
PFNNRWYQMG
590
IVSWGEGCDR
600
DGKYGFYTHV
610
FRLKKWMQKV
IDRFGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.