Search Results
Overview
| Uniprot ID | A0A8W4FG96 |
|---|---|
| Protein Name | Mitogen-activated protein kinase |
| Gene Name | MAPK1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 270 | LSLPHKNKVPWNRLF |
| 342 | DLPKEKLKELIFEET |
| 53 | KVRVAIKKISPFEHQ |
Function
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity
Protein Sequence
10
LGPLPRPFGP
20
MVRGQVFDVG
30
PRYTNLSYIG
40
EGAYGMVCSA
50
YDNVNKVRVA
60
IKKISPFEHQ
70
TYCQRTLREI
80
KILLRFRHEN
90
IIGINDIIRA
100
PTIEQMKDVY
110
IVQDLMETDL
120
YKLLKTQHLS
130
NDHICYFLYQ
140
ILRGLKYIHS
150
ANVLHRDLKP
160
SNLLLNTTCD
170
LKICDFGLAR
180
VADPDHDHTG
190
FLTEYVATRW
200
YRAPEIMLNS
210
KGYTKSIDIW
220
SVGCILAEML
230
SNRPIFPGKH
240
YLDQLNHILG
250
ILGSPSQEDL
260
NCIINLKARN
270
YLLSLPHKNK
280
VPWNRLFPNA
290
DSKALDLLDK
300
MLTFNPHKRI
310
EVEQALAHPY
320
LEQYYDPSDE
330
PIAEAPFKFD
340
MELDDLPKEK
350
LKELIFEETA
RFQPGYRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004707 | MAP kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0035556 | intracellular signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.