Search Results

Overview

Uniprot IDA0A8W4FGZ0
Protein NameUbiquitin conjugation factor E4
Gene NameUBE4B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1248 KSTIAIEKFKLLAEK

Function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates

Protein Sequence

10 MEELSADEIR 20 RRRLARLAGG 30 QTSQPTTPLT 40 SPQRENPPGP 50 PIAASAPGPS 60 QSLGLNVHSM 70 TPATSPIGAS 80 GVAHRSQSSE 90 GVSSLSSSPS 100 NSLETQSQSL 110 SRSQSMDIDG 120 VSCEKSLSQV 130 DVDSGIENME 140 VDENDRREKR 150 SLSDKEPSSG 160 SEVSEEQALQ 170 LVCKILRVSW 180 KDRDRDVIFL 190 SSLSAQFKQN 200 PKEVFSDFKD 210 LIGQILMEVL 220 MMSTQTRDEN 230 PFASLTATSQ 240 PIAAAARSPD 250 RNLLLNAGSN 260 PGTSPMFCSA 270 GSFGASSLSS 280 LYETSPAPRT 290 SFWSSGPMTS 300 PPLASPSRAA 310 SQAAPGPHGA 320 GAGAPAGSQS 330 PSPRYRPYTV 340 THPWGSSSLC 350 LLSGSPGLPT 360 LASSPQAVPA 370 GSSGPRSSSA 380 GPPLLSASPG 390 AVSRRPASFR 400 SSPSMYDTPF 410 SFLFLALSGD 420 SSDEDGEEDG 430 DGADGADEGG 440 GGGDEFSCVP 450 FGSSLGASGG 460 ASTWDSYSDH 470 FTIETCKETD 480 MLNYLIECFD 490 RVGIEEKKAP 500 KMCSQPAVSQ 510 LLSNIRSQCI 520 SHTALVLQGS 530 LTQPRSMQQP 540 SFLVPYMLCR 550 NLPYGFIQEL 560 VRTTHQDEEV 570 FKQIFIPILQ 580 GLALAAKECS 590 LDSDYFKYPL 600 MALGELCETK 610 FGKTHPVCNL 620 VASLPLWLPK 630 SLSPGSGREL 640 QRLSYLGAFF 650 SFSVFAEDDA 660 KVVEKYFSGP 670 AITLENTRVV 680 SQSLQHYLEL 690 GRQELFKILH 700 SILLNGETRE 710 AALGYMAAVV 720 NANMKKAQMQ 730 TDDRLVSTDG 740 FMLNFLWVLQ 750 QLSTKIKLET 760 VDPTYIFHPR 770 CRITLPNDET 780 RVNATMEDVN 790 DWLTELYGDQ 800 PPYSEPKFPT 810 ECFFLTLHAH 820 HLSILPSCRR 830 YIRRLRAIRE 840 LNRTVEDLKN 850 NESQWKDSPL 860 ATRHREMLKR 870 CKTQLKKLVR 880 CKACADAGLL 890 DESFLRRCLN 900 FYGLLIQLLL 910 RILDPAYPDV 920 TLPLNSDVPK 930 VFAALPEFYV 940 EDVAEFLFFI 950 VQYSPQVLYE 960 PCTQDIVMFL 970 VVMLCNQNYI 980 RNPYLVAKLV 990 EVMFMTNPAV 1000 QPRTQKFFEM 1010 IENHPLSTKL 1020 LVPSLMKFYT 1030 DVEHTGATSE 1040 FYDKFTIRYH 1050 ISTIFKSLWQ 1060 NLAHHGTFMD 1070 EFNSGKQFVR 1080 YINMLINDTT 1090 FLLDESLESL 1100 KRIHEVQEEM 1110 KNKEQWDQLP 1120 RDQQQARQSQ 1130 LAQDERVSRS 1140 YLALATETVD 1150 MFHILTKQVQ 1160 KPFLRPELGP 1170 RLAAMLNFNL 1180 QQLCGPKCRD 1190 LKVENPEKYG 1200 FEPKKLLDQL 1210 TDIYLQLDCA 1220 RFAKAIADDQ 1230 RSYSKELFEE 1240 VISKMRKAGI 1250 KSTIAIEKFK 1260 LLAEKVEEIV 1270 AKNARAEIDY 1280 SDAPDEFRDP 1290 LMDTLMTDPV 1300 RLPSGTIMDR 1310 SIILRHLLNS 1320 PTDPFNRQTL 1330 TESMLEPVPE 1340 LKEQIHAWMR EKQNSDH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000151 ubiquitin ligase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0008626 granzyme-mediated apoptotic signaling pathway
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0009411 response to UV
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.