Search Results

Overview

Uniprot IDA0A8W4FH88
Protein NameExportin-5
Gene NameXPO5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1140 LLNPSLQKAADKRRK
1160 LIAGCIGKPLGEQFR
1173 FRKEVHIKNLPSLFK
208 VNKYQQVKTDNAQES
35 RYRLEALKFCEEFKE
41 LKFCEEFKEKCPICV
43 FCEEFKEKCPICVPC
57 CGLRLAEKTQIAIVR
87 NSMSRLEKVYLKNSV
931 LHMRLSQKWQIINQR
980 ITVCCVSKKGADHTA

Function

Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP

Protein Sequence

10 MAMDQVNALC 20 EELVKAVTVM 30 MDPSSTQRYR 40 LEALKFCEEF 50 KEKCPICVPC 60 GLRLAEKTQI 70 AIVRHFGLQI 80 LEHVVKFRWN 90 SMSRLEKVYL 100 KNSVMELTAN 110 GTLDILEEEN 120 HIKDVLSRIV 130 VEMIKREWPQ 140 HWPDMLVELD 150 TLSKQGETQT 160 ELVMFILLRL 170 AEDVVTFQTL 180 PPQRRRDIQQ 190 TLTQNMEKIF 200 SFLLNTLQEN 210 VNKYQQVKTD 220 NAQESKAQAY 230 CRVAIAALNT 240 LAGYTDWVSL 250 SHITAENCKL 260 LEMLCLLLSE 270 QELQLGAAEC 280 LLIAVSRKGK 290 LEDRKPLMIL 300 FGDAVMHYML 310 SAAQTADGGG 320 LVEKHYVFLK 330 RLCQVLCALG 340 SQLCALLGPD 350 SDVETPANFG 360 KYLESFLAFT 370 THPSQFLRSS 380 TQMTWGALFR 390 HEVLSRDPLL 400 LAIIPKYLRA 410 CMTNLVKMGF 420 PSKTDNPSCE 430 YSRLDFDSDE 440 DFNAFFNSSR 450 AQQGEVMRLA 460 CRLDPKTSFQ 470 MAGEWLKYQL 480 SAAIDTGSMK 490 SVPPTAGSGE 500 SGLCSIFSPS 510 FVQWEAMTFF 520 VEGVVNQMFR 530 TVDKEEIPVN 540 DGIELLQMVL 550 NFETKDPLIL 560 SCVLTNVSAL 570 FSFVTFRPEF 580 LPQVFSKLFS 590 SVTFEIVEES 600 KAPRTRAVRN 610 VRRHACSSII 620 KMCRDYPQLV 630 LPNFDMLYDH 640 VKQLLSNELL 650 LTQMEKCALM 660 EALVLISNQF 670 KNYERQKLFI 680 EELMAPVASI 690 WLSEEMHRAL 700 SDADAFLAFV 710 GADQKSYDLV 720 QEDPCGLNRA 730 RMSFCVYSIL 740 GVVKRTSWPP 750 DLEEAKAGGF 760 VVGYTPTGNP 770 IFRNPCTEQV 780 LKLLDNLLAL 790 IRTHNSLYAP 800 EMLAKLGEPF 810 SKALDMIDAE 820 KSTILGLPQP 830 LLDLNDSPVY 840 KTILEKMQRF 850 FCTLYENCFH 860 ILGKAGPSMQ 870 QDFYTVEQLS 880 TQLLSSAFVN 890 LDNLPDYRLR 900 PLLRVFVKPL 910 VLACTPEYYE 920 SLVSPIVGPL 930 FTYLHMRLSQ 940 KWQIINQRSM 950 LCEDETTDEN 960 PESQEMLEEQ 970 LVRMLTREVV 980 DLITVCCVSK 990 KGADHTATPA 1000 ADGEDEEMMA 1010 TEVATPATAE 1020 LTDLGKCLTK 1030 HEDVCTALLI 1040 LAFNSLAWKD 1050 TLSCQRTTTQ 1060 LCWPLLKQVL 1070 SGTLLAEAVT 1080 WLFTSVLKGL 1090 QTHGQHDGCM 1100 ASLVHLAFQT 1110 YEALRPRYVE 1120 IRAVMEQIPD 1130 IQKESLDQFD 1140 CKLLNPSLQK 1150 AADKRRKDQF 1160 KRLIAGCIGK 1170 PLGEQFRKEV 1180 HIKNLPSLFK 1190 KTKPTHDSDA 1200 LDNDEGGLAT IFEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016442 RISC complex
Cellular Component GO:0042565 RNA nuclear export complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0070883 pre-miRNA binding
Molecular Function GO:1905172 RISC complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0035281 pre-miRNA export from nucleus
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0006405 RNA export from nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.