Overview
| Uniprot ID | A0A8W4FIB6 |
|---|
| Protein Name | Calnexin |
|---|
| Gene Name | CANX |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 100 |
DTDDEIAKYDGKWEV |
| 114 |
VDEMKETKLPGDKGL |
| 119 |
ETKLPGDKGLVLLSR |
| 135 |
KHHAISTKLNKPFIF |
| 138 |
AISTKLNKPFIFDTK |
| 171 |
AYVKLLSKTPELNLD |
| 211 |
IFRHKNPKTGVYEEK |
| 218 |
KTGVYEEKHAKRPDA |
| 234 |
LKTYFTDKKTHLYTL |
| 293 |
EDWDERPKIPDPDAV |
| 436 |
LFCCSGKKQASPVEY |
| 91 |
WILSKAKKDDTDDEI |
Function
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse
Protein Sequence
10
MEGKWLLCML
20
LVLGTAVVQA
30
HDGHDDDVID
40
IEDDLDDVIE
50
EVEDSKPKPD
60
TSAPPSPKVT
70
YKAPVPTGEV
80
YFADSFDRGT
90
LSGWILSKAK
100
KDDTDDEIAK
110
YDGKWEVDEM
120
KETKLPGDKG
130
LVLLSRAKHH
140
AISTKLNKPF
150
IFDTKPLIVQ
160
YEVNFQNGIE
170
CGGAYVKLLS
180
KTPELNLDQF
190
HDKTPYTIMF
200
GPDKCGEDYK
210
LHFIFRHKNP
220
KTGVYEEKHA
230
KRPDADLKTY
240
FTDKKTHLYT
250
LILNPDNSFE
260
ILVDQAVVNS
270
GNLLNDMTPP
280
VNPSREIEDP
290
EDRKPEDWDE
300
RPKIPDPDAV
310
KPDDWDEDAP
320
AKIPDEEATK
330
PIGWLDDEPE
340
YVPDPDAEKP
350
EDWDEDMDGE
360
WEAPQIANPK
370
CESAPGCGVW
380
QRPMIDNPNY
390
KGKWKPPMID
400
NPNYQPGVVG
410
QMIEAAEERP
420
WLWVVYILTV
430
ALPVFLVILF
440
CCSGKKQASP
450
VEYKKTDAPQ
460
PDVKEEEEEK
470
EEEKEKGDEE
480
EEGEEKLEEK
490
QKSDAEEDGG
500
TVSQEEEDRK
510
PKAEEDEILN
520
RSPRNRKPRR
E
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0033162 |
melanosome membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Molecular Function |
GO:0051082 |
unfolded protein binding |
| Biological Process |
GO:0006457 |
protein folding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.