Search Results

Overview

Uniprot ID	A0A8W4FIK8
Protein Name	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Gene Name	SUCLA2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
116	GTFESGLKGGVKIVF
120	SGLKGGVKIVFSPEE
395	GTRVDDAKALIADSG
88	DEAYAIAKKLGSKDV

Function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase

Protein Sequence

10 MAASMFYSRL 20 LAAATLRNHR 30 PRTALQTAAQ 40 VLGSSGLFNN 50 HGLQIQQQQQ 60 RNLSLHEYMS 70 MELLQEAGVS 80 IPKGHVAKSP 90 DEAYAIAKKL 100 GSKDVVIKAQ 110 VLAGGRGKGT 120 FESGLKGGVK 130 IVFSPEEAKA 140 VSSQMIGKKL 150 FTKQTGEKGR 160 ICNQVLVCER 170 RYPRREYYFA 180 ITMERSFQGP 190 VLIGSSQGGV 200 NIEDVAAETP 210 EAIVKEPIDI 220 VEGIKKEQAV 230 RLAQKMGFPP 240 SIVDSAAENM 250 IKLYNLFLKY 260 DATMVEINPM 270 VEDKKIFDLQ 280 DWTQEDERDK 290 DAAKANLNYI 300 GLDGNIGCLV 310 NGAGLAMATM 320 DIIKLHGGTP 330 ANFLDVGGGA 340 TVHQVTEAFK 350 LITSDKKVLS 360 ILVNIFGGIM 370 RCDVIAQGIV 380 MAVKDLEIKI 390 PIVVRLQGTR 400 VDDAKALIAD 410 SGLKILACDD 420 LDEAAKMVNR LC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004775	succinate-CoA ligase (ADP-forming) activity
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.