Overview
| Uniprot ID | A0A8W4FIU8 |
|---|
| Protein Name | Protein SEC13 homolog |
|---|
| Gene Name | SEC13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 209 |
QKPNYIKKFASGGCD |
| 57 |
CSSDRSVKIFDVRNG |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
MSGRLVQTRL
20
SVLVTTPPHT
30
HPRSLQAAPA
40
LLPLQHDAQM
50
DYYGTRLATC
60
SSDRSVKIFD
70
VRNGGQILIA
80
DLRGHEGPVW
90
QVAWAHPMYG
100
NILASCSYDR
110
KVIIWKEENG
120
TWEKTHEHTG
130
HDSSVNSVCW
140
APHDYGLILA
150
CGSSDGAISL
160
LTYTGLGQWE
170
VKKINNAHTV
180
IPSMLLQMIG
190
CNAVSWAPAV
200
VPGSLIDQPS
210
GQKPNYIKKF
220
ASGGCDNLIK
230
LWKEEEDGQW
240
KEEQKLEAHS
250
DWVRDVAWAP
260
SIGLPTSTIA
270
SCSQDGRVFI
280
WTCDDASGNT
290
WSPKLLHKFN
300
DVVWHVSWSI
310
TANILAVSGG
320
DNKVTLWKES
330
VDGQWVCISD
340
VNKGQGSVST
350
SITEGQQNEQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030127 |
COPII vesicle coat |
| Cellular Component |
GO:0061700 |
GATOR2 complex |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0031080 |
nuclear pore outer ring |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0031669 |
cellular response to nutrient levels |
| Biological Process |
GO:0090110 |
COPII-coated vesicle cargo loading |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:1904263 |
positive regulation of TORC1 signaling |
| Biological Process |
GO:0032527 |
protein exit from endoplasmic reticulum |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.