Overview
| Uniprot ID | A0A8W4FJI1 |
|---|
| Protein Name | U6 snRNA-associated Sm-like protein LSm6 |
|---|
| Gene Name | LSM6 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 5 |
***MSLRKQTPSDFL |
| 59 |
VNGQLKNKYGDAFIR |
| 77 |
VLYISTQKRRM**** |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway
Protein Sequence
10
MSLRKQTPSD
20
FLKQIIGRPV
30
VVKLNSGVDY
40
RGVLACLDGY
50
MNIALEQTEE
60
YVNGQLKNKY
70
GDAFIRGNNV
80
LYISTQKRRM
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0006364 |
rRNA processing |
| Biological Process |
GO:0008033 |
tRNA processing |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0120115 |
Lsm2-8 complex |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Molecular Function |
GO:0003723 |
RNA binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.