Overview
| Uniprot ID | A0A8W4FJJ4 |
|---|
| Protein Name | Acetyltransferase component of pyruvate dehydrogenase complex |
|---|
| Gene Name | DLAT |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 259 |
PATPAGPKGRLFVSP |
| 269 |
LFVSPLAKKLASEKG |
| 283 |
GIDLTQIKGTGPDGR |
| 294 |
PDGRIIKKDIDSFVP |
| 380 |
KMLEGRSKISVNDFI |
Function
The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation
Protein Sequence
10
MWRVCARRAQ
20
NAAPRAGFGA
30
RWTALREEPG
40
APCAAPRAGS
50
VPARCSSTTR
60
GYGRSRALCG
70
WSASSWATPQ
80
NRILLQLWGS
90
PNRRWYSLPP
100
HQKVPLPSLS
110
PTMQAGTIAR
120
WEKKEGDKIN
130
EGELIAEVVL
140
PALSPTMTMG
150
TVQRWEKKVG
160
EKLSEGDLLA
170
EIETDKATIG
180
FEVQEEGYLA
190
KILIPEGTRD
200
VPLGTPLCII
210
VEKEADIPAF
220
ADYRPTEVTD
230
LKPPAPPPTP
240
SPVTPVPPAP
250
QPVAPTPAAT
260
RPATPAGPKG
270
RLFVSPLAKK
280
LASEKGIDLT
290
QIKGTGPDGR
300
IIKKDIDSFV
310
PTKAAPPPAA
320
AVPPPSPGVA
330
PVPTGVFTDI
340
PISNIRRVIA
350
QRLMQSKQTI
360
PHYYLSVDVN
370
MGEVLLVRKE
380
LNKMLEGRSK
390
ISVNDFIIKA
400
SALACLKVPE
410
ANSSWLDTVI
420
RQNHVVDISV
430
AVSTPAGLIT
440
PIVFNAHIKG
450
LETIANDVVS
460
LATKAREGKL
470
QPHEFQGGTF
480
TISNLGMFGI
490
KNFSAIINPP
500
QACILAVGAS
510
EDRLFPADNE
520
KGFDVASMMS
530
VTLSCDHRVV
540
DGAVGAQWLA
550
EFRKYLEKPI
TMLL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0045254 |
pyruvate dehydrogenase complex |
| Molecular Function |
GO:0004742 |
dihydrolipoyllysine-residue acetyltransferase activity |
| Biological Process |
GO:0006006 |
glucose metabolic process |
| Biological Process |
GO:0006086 |
pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.