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Overview

Uniprot IDA0A8W4FJW8
Protein NameTrifunctional purine biosynthetic protein adenosine-3
Gene NameGART
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
156 ASGLAAGKGVIIAES
28 LAQSNHVKQVLVTPG

Function

Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway

Protein Sequence

10 MAAQVLVIGN 20 GGREHTLAWK 30 LAQSNHVKQV 40 LVTPGNAGTA 50 SSEKISNTDV 60 SVSDHAALAQ 70 FCKEEKIEFV 80 VVGPEAPLAA 90 GIVGNLTSAG 100 VRCFGPTAEA 110 AQLESSKRFA 120 KEFMDRHGIP 130 TAQWRAFTKP 140 EEACSFIMSA 150 DFPALVVKAS 160 GLAAGKGVII 170 AESKEEACKA 180 VQEIMQDRAF 190 GEAGETIVIE 200 ELLEGEEVSC 210 LCFTDGRTVA 220 PMPPAQDHKR 230 LLDGDHGPNT 240 GGMGAYCPAP 250 QVSKDLLLKI 260 KDTILQKTVA 270 GMQQEGVPYT 280 GILYAGIMLT 290 KNGPKVLEFN 300 CRFGDPECQV 310 ILPLLKSDLY 320 EVIQATLDGR 330 LCTSLPVWHD 340 NRAAVTVVMA 350 SKGYPGDYTK 360 GVEITGFHEA 370 QALGLEVFQA 380 GTALKDGKVV 390 TNGGRVLTVT 400 AIQENLISAL 410 EEAKKGLAAI 420 KFEGAIYRKD 430 IGCRAIAFLQ 440 QPRGLTYKES 450 GVDIAAGNML 460 VKKIKPLAKA 470 TSRPGCDVDL 480 GGFAGLFDLK 490 AAGFSDPLLA 500 CGTDGVGTKL 510 KIAQQCHKHD 520 TIGQDLVAMC 530 VNDILAQGAE 540 PLFFLDYFSC 550 GKLDLNTTEA 560 VVAGIAEACK 570 KAGCALLGGE 580 AEMPDMYPPG 590 EYDLAGFAVG 600 AMERDQKLPH 610 LERITEGDAV 620 IGVASSGLHS 630 NGFSLVRKII 640 AKSSLQYSSP 650 APDGCGDQTL 660 GDLLLTPTRI 670 YSHSLLPVLR 680 SGHVKAFAHI 690 TGGGLLENIP 700 RVLPQKFGVD 710 LDARTWRIPR 720 IFSWLQQLGH 730 LSEEEMARTF 740 NCGIGAALVV 750 SKDLTEQILQ 760 DIERHKEEAW 770 VIGKVVACPE 780 GSPRVKVKHL 790 IESMQINGSV 800 LENGTLKNHF 810 SVQPKKARVA 820 VLISGTGSNL 830 QALIESTQAP 840 SSSAHIIVVI 850 SNKAAVAGLD 860 KAARAGIPTR 870 VINHKLYKDR 880 VAFDMAVDQV 890 LEEFSTDIVC 900 LAGFMRILSG 910 PFVRKWNGKM 920 LNIHPSLLPS 930 FKGSNAHEQV 940 LDAGVTVTGC 950 TVHFVAEDVD 960 AGQIVLQEAV 970 PVKRGDTIET 980 LSERVKLAEH 990 KIFPSALQLV 1000 ASGTVQLGEN GKIRWVREE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004637 phosphoribosylamine-glycine ligase activity
Molecular Function GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Function GO:0004644 phosphoribosylglycinamide formyltransferase activity
Biological Process GO:0044208 'de novo' AMP biosynthetic process
Biological Process GO:0006189 'de novo' IMP biosynthetic process
Biological Process GO:0097294 'de novo' XMP biosynthetic process
Biological Process GO:0046084 adenine biosynthetic process
Biological Process GO:0006177 GMP biosynthetic process
Biological Process GO:0006164 purine nucleotide biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.