Search Results
Overview
| Uniprot ID | A0A8W4FK74 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | DCTN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | DKFSQAAKVAELEKR |
| 208 | AKVAELEKRLTELEA |
| 276 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MADPKYADLP
20
GIEELTSTSV
30
EHIIVNPNAA
40
YDKFKDKRVG
50
TKGLDFSDRI
60
GKTKRTGYES
70
GEYEMLGEGL
80
GVKETPQQKY
90
QRLLHEVQEL
100
TTEVEKIKMT
110
VKESATEEKL
120
TPVVLAKQLA
130
ALKQQLVASH
140
LEKLLGPDAA
150
INLTDPDGAL
160
AKRLLLQLEA
170
TKNTKGAGSG
180
GKTTSGSPPD
190
SSLVTYELHS
200
RPEQDKFSQA
210
AKVAELEKRL
220
TELEATVRCD
230
QDAQNPLSAG
240
LQGACLMETV
250
ELLQAKVSAL
260
DLAVLDQVEA
270
RLQSVLGKVN
280
EIAKHKASVE
290
DADTQSKVHQ
300
LYETIQRWSP
310
IASTLPELVQ
320
RLVTIKQLHE
330
QAMQFGQLLT
340
HLDTTQQMIA
350
CSLKDNATLL
360
TQVQTTMREN
370
LSTVEGNFAN
380
IDERMKKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.