Search Results
Overview
| Uniprot ID | A0A8W4FKB1 |
|---|---|
| Protein Name | Glucose-6-phosphate 1-dehydrogenase |
| Gene Name | G6PD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | FKATPEEKPRLEEFF |
| 211 | WNRVIVEKPFGRDLQ |
| 400 | PFILRCGKALNERKA |
| 426 | DIFQQQCKRNELVIR |
| 511 | IFTPLLHKIEREKLQ |
| 554 | YKWVNPHKL****** |
Function
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP
Protein Sequence
10
MGTRASCGEL
20
HTDSRSIGDT
30
AQRRRGQQGA
40
RSPAAGAEST
50
MAEQVALSRT
60
QVCGILREEL
70
YQGDAFHQSD
80
THIFIIMGAS
90
GDLAKKKIYP
100
TLWWLFRDGL
110
LPEDTYIVGY
120
ARSRLSVADI
130
RRQSEPFFKA
140
TPEEKPRLEE
150
FFARNSYVAG
160
QYDDAASYAR
170
LNSHMNALHQ
180
GSQANRLFYL
190
ALPPTVYEAV
200
TKNIRETCMS
210
RAGWNRVIVE
220
KPFGRDLQSS
230
DQLSNHISSL
240
FREDQIYRID
250
HYLGKEMVQN
260
LMVLRFANRI
270
FGPIWNRDNI
280
ACVILTFKEP
290
FGTEGRGGYF
300
DEFGIIRDVM
310
QNHLLQMLCL
320
VAMEKPASTD
330
SDDVRDEKVK
340
VLKCISEVQA
350
SNVVLGQYVG
360
NPNGEGEATR
370
GYLDDPTVPC
380
GSTTATFAAV
390
VLYVENERWD
400
GVPFILRCGK
410
ALNERKAEVR
420
LQFRDVAGDI
430
FQQQCKRNEL
440
VIRVQPDEAV
450
YTKMMTKKPG
460
MFFSPEESEL
470
DLTYGNRYKN
480
VKLPDAYERL
490
ILDVFCGSQM
500
HFVRSDELRE
510
AWRIFTPLLH
520
KIEREKLQPI
530
PYVYGSRGPP
540
EADELMKRVG
550
FQYEGTYKWV
NPHKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004345 | glucose-6-phosphate dehydrogenase activity |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006098 | pentose-phosphate shunt |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.