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Overview

Uniprot IDA0A8W4FKV9
Protein NameLarge proline-rich protein BAG6
Gene NameBAG6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
56 SVSIPSEKQRLIYQG

Function

Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2)

Protein Sequence

10 MEPNDSTSTT 20 MEEPESLEVL 30 VKTLDSQTRT 40 FIVGAQMNVK 50 EFKEHIAASV 60 SIPSEKQRLI 70 YQGRVLQDDK 80 KLQEYNVGGK 90 VIHLVERAPP 100 QTQLPSGASS 110 GTGSASATHG 120 GGPPPGTRGP 130 GASVHDRNAN 140 SYVMVGTFNL 150 PSEPRVRLVM 160 AQHMIRDIQT 170 LLSRMECRGG 180 SQAQHSQPPS 190 QMPTVAPEPV 200 ALSSQTSESV 210 ESEVPPREPM 220 AAEEVEERAS 230 AQSPGLSSGP 240 APAGPTPAPE 250 TNAPNHPSPA 260 EYVEVLQELQ 270 RLESRLQPFL 280 QRYYEVLGAA 290 ATTDYNNNQE 300 GREEDQRLIN 310 LVGESLRLLG 320 NTFVALSDLR 330 CNLACAPPRH 340 LHVVRPMSHY 350 TTPMVLQQAA 360 IPIQINVGTT 370 VTMTGNGTRP 380 PPTPNAEAPP 390 PGPGQASSLA 400 PSSTTVESST 410 EGAPPPGPAP 420 PPAASHPRVI 430 RISHQSVEPV 440 VMMHMNIQDS 450 GTQPGGVPSA 460 PTGPLGPTGH 470 GQTLGQQVPG 480 FPTAPTRVVI 490 ARPTPPQSRP 500 SHPGGPPVSG 510 ALPGAGLGTN 520 ASLAQMVSGL 530 VGQLLMQPVL 540 VAQGTPGMAP 550 PPAPATASAS 560 AGTTNTATTA 570 GPAPGGPAQP 580 PPPQPSASDL 590 QFSQLLGNLL 600 GPAGPGAGGP 610 GMTSPTITVA 620 MPGVPAFLQG 630 MTDFLQATQT 640 AAPPAPPPPP 650 PPPPPAPEQQ 660 TAPPPGSPPG 670 GAGSPGGLGP 680 ESLPLEFFTS 690 VVQGVLSSLL 700 GSLGARAGSS 710 ESIAAFIQRL 720 SGSSNIFEPG 730 ADGALGFFGA 740 LLSLLCQNFS 750 MVDVVMLLHG 760 HFQPLQRLQP 770 QLRSFFHQHY 780 LGGQEPTPGN 790 IRTATHTLIT 800 GLEEYVRESF 810 SLVQVQPGVD 820 IIRTNLEFLQ 830 EQFNSIAAHV 840 MHCTDSGFGA 850 RLLELCNQGL 860 FECLALNLHC 870 LGGQQMELAA 880 VINGRIRRMS 890 RGVNPSLVSW 900 LTTMMGLRLQ 910 VVLEHMPVGP 920 DAILRYVRRV 930 GDPPQPLPEE 940 PMEVQGSERT 950 SPEPQRENAS 960 PAPGTTAEEA 970 MSRGPPPAPE 980 GGSRDEQDGA 990 AAETEPWAAA 1000 VPPEWVPIIQ 1010 QDIQSQRKVK 1020 PQPPLSDAYL 1030 SGMPAKRRKT 1040 MQGEGPQLLL 1050 SEAVSRAAKA 1060 AGARPLTSPE 1070 SLSRDLEAPE 1080 VQESYRQQLR 1090 ADIQKRLQED 1100 PNYSPQRFPN AHRAFAEDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005634 nucleus
Biological Process GO:0006915 apoptotic process
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006325 chromatin organization
Biological Process GO:0002376 immune system process
Biological Process GO:0007283 spermatogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.